Human papillomavirus effect on the development of endometrial polyps

Aim: Although the association of human papillomavirus (HPV) with warts arising in different parts of the human body has been welldemonstrated, the association of HPV with endometrial polyps has never been studied in the literature up to now. Materials and Methods: Detection of the HPV DNA was carried out by using 13 high-risk HPV real-time PCR Kit and five low-risk HPV real-time PCR Kit. Results: Among 50 endometrial polyp samples, one endometrial polyp sample revealed a positive result for the presence of HPV type 18. Conclusions: This first study in the medical literature investigating the possible effect of HPV on the development of endometrial polyps has demonstrated that HPV might have a role in the development of some of the endometrial polyps. If the present authors’ hypothesis that endometrial polyps caused by carcinogenic HPV types are prone to proceed to endometrial cancer if left untreated is correct, HPV vaccine has a potential to prevent development of at least some of the endometrial polyps and endometrial cancers.

HPV; Vaccine; Endometrial polyp; Endometrial cancer; Warts.

[1] Koutsky L.: “Epidemiology of genital human papillomavirus infection”. Am. J. Med., 1997, 102,3.

[2] Munoz N.: “Human papillomavirus and cancer: the epidemiological evidence”. J. Clin. Virol., 2000, 19, 1.

[3] Steenbergen R.D., de Wilde J., Wilting S.M., Brink A.A., Snijders P. J., Meijer C.J.: “HPV-mediated transformation of the anogenital tract”. J. Clin. Virol., 2005, 32, S25.

[4] D’Souza G., Kreimer A.R., Viscidi R., Pawlita M., Fakhry C., Koch W. M., et al.: “Case-control study of human papillomavirus and oropharyngeal cancer”. N. Engl. J. Med., 2007, 356, 1944.

[5] Heatley M.K.: “Squamous intraepitheial lesions arising in benign endocervical polyps: a report of 9 cases with correlation to the pap smears, HPV analysis and immunoprofile”. Int. J. Gynecol. Pathol., 2009, 28, 567.

[6] Sham C.L., To K.F., Chan P.K., Lee D.L., Tong M.C., van Hasselt C. A.: “Prevalence of human papillomavirus, Epstein-Barr virus, p21 and p53 expression in sinonasal inverted papilloma, nasal polyp and hypertrophied turbinate in Hong Kong patients”. Head Neck, 2012, 34, 520.

[7] Hoffmann M., Klose N., Gottschlich S., Görögh T., Fazel A., Lohrey C., et al.: “Detection of human papillomavirus DNA in benign and malignant sinonasal neoplasms”. Cancer Lett., 2006, 239, 64.

[8] Bruggink S.C., de Koning M.N., Gussekloo J., Egberts P.F., Ter Schegget J., Feltkamp M.C., et al.: “Cutaneous wart-associated HPV types: prevalence and relation with patient characteristics”. J. Clin. Virol., 2012, 55, 250.

[9] Lizano M., Berumen J., Garcia-Carranca A.: “HPV-related car-cinogenesis: basic concepts, viral types and variants”. Arch. Med. Res., 2009, 40, 428.

[10] World Health Organization: “IARC monographs on the evaluation of carcinogenic risk to humans. Vol. 64: Human papillomaviruses”. Lyon: International Agency for Research on Cancer, 1995. Avail-able at: http://monographs.iarc.fr/ENG/Monographs/vol64/mono64- 1.pdf

[11] Moody C.A., Laimins L.A.: “Human papillomavirus oncoproteins: pathways to transformation”. Nat. Rev. Cancer, 2010, 10, 550.

[12] Sisk E.A., Robertson E.S.: “Clinical implications human papillomavirus infection”. Front. Biosci., 2002, 7, 77.

[13] Schiffman M., Castle P.E., Jeronimo J., Rodriguez A.C., Wacholder S.: “Human papillomavirus and cervical cancer”. Lancet, 2007, 370, 890.

[14] Wang S.S., Zuna R.E., Wentzensen N., Dunn S.T., Sherman M.E., Gold M.A., et al.: “Human papillomavirus cofactors by disease pro-gression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants”. Cancer Epidemiol. Biomarkers Prev., 2009, 18, 113.

[15] Kirgan D., Manalo P., Hall M., McGregor B.: “Association of human papillomavirus and colon neoplasm”. Arch. Surg., 1990, 125, 862.

[16] Damin D.C., Ziegelmann P.K., Damin A.P.: “Human papillomavirus infection and colorectal cancer risk: a meta-analysis”. Colorectal Dis., 2013, 15, e420. doi: 10.1111/codi.12257.