Surgical removal of an isolated femoral metastasis of uterine cervical squamous cell carcinoma: a case report and review of the literature

A bone metastasis from uterine cervical cancer normally indicates short life expectancy. Resection of the lesion is therefore palliative. The authors consider herein whether surgical resection can promote disease control while improving quality of life. A 33-year-old woman presenting FIGO Stage IB1 uterine cervical squamous cell carcinoma underwent a radical hysterectomy and pelvic irradiation. Twenty-two-months later, a solitary femoral metastasis was detected. Given the pain, imminent bone fracture, the patient’s relative youth, absence of other metastases, and complete control of the primary lesion, wide excision of the lesion, and reconstruction were performed. Sixteen months later, she was disease-free and ambulatory using a cane. The findings of both the present case and the review showed that patients were disease-free for over one year after surgery, suggesting that resection may assist disease control as well as improve patients’ quality of life.

Bone metastasis; Cervical cancer; Femur; Tumor resection.

[1] Disibio G., French S.W.: “Metastatic patterns of cancers: results from a large autopsy study”. Arch. Pathol. Lab. Med., 2008, 132, 931.

[2] Yoon A., Choi C.H., Kim H.J., Park J.Y., Lee Y.Y., Kim T.J., et al.: “Contributing factors for bone metastasis in uterine cervical cancer”. Int. J. Gynecol Cancer, 2013, 23, 1311.

[3] Thanapprapasr D., Nartthanarung A., Likittanasombut P., Na Ayudhya N.I., Charakorn C., Udomsubpayakul U., et al.: “Bone metastasis in cervical cancer patients over a 10-year period”. Int. J. Gynecol. Cancer, 2010, 20, 373.

[4] Matsuyama T., Tsukamoto N., Imachi M., Nakano H.: “Bone metastasis from cervix cancer”. Gynecol. Oncol., 1989, 32, 72.

[5] Ji T., Eskander R., Wang Y., Sun K., Hoang B.H., Guo W.: “Can surgical management of bone metastases improve quality of life among women with gynecologic cancer?” World J. Surg. Oncol., 2014, 12, 250.

[6] Yuan F., Zhang C., Cui Z., Li X., Li X., Lin W., et al.: “Cervical squamous cell carcinoma with isolated tibial metastasis: A case report and review of the literature”. Oncol. Lett., 2014, 8, 2535.

[7] Malek M., Kanafi A.R., Pourghorban R., Nafisi-Moghadam R.: “Isolated humeral metastasis in uterine cervical cancer: a rare entity”. J. Clin. Imaging Sci., 2012, 2, 80.

[8] Corrado G., Santaguida S., Zannoni G., Scambia G., Ferrandina G.: “Femur metastasis in carcinoma of the uterine cervix: a rare entity”. Arch. Gynecol. Obstet., 2010, 281, 963.

[9] Pasricha R., Tiwari A., Aggarwal T., Lal P.: “Carcinoma of uterine cervix with isolated metastasis to fibula and its unusual behavior: report of a case and review of literature”. J. Cancer. Res. Ther., 2006, 2, 79.