Article Menu

Export Article

More by Authors Links

Article Data

  • Views 492
  • Dowloads 114

Case Reports

Open Access

Lymphoepithelioma-like carcinoma of the uterine cervix: a case report

  • H. Kyozuka1,*,
  • T. Watanabe1
  • S. Furukawa1
  • S. Soeda1
  • Y. Kiko2
  • K. Fujimori1

1Department of the Obstetric and Gynecology, School of Medicine, Fukushima Medical University, Fukushima, Japan

2Department of the Diagnostic Pahology, School of medicine, Fukushima Medical University, Fukushima, Japan

DOI: 10.12892/ejgo3499.2017 Vol.38,Issue 3,June 2017 pp.459-461

Published: 10 June 2017

*Corresponding Author(s): H. Kyozuka E-mail: Kyozuka@fmu.ac.jp

PDF (1.23 MB)

Abstract

Lymphoepithelioma-like carcinoma (LELC) is a rare variant of carcinoma of the uterine cervix, of which Epstein-Barr virus (EBV) and/or human papilloma virus (HPV) may play an important role in the pathogenesis. The authors report a case of a patient with cervical LELC who was also examined for the presence of EBV and HPV. A 31-year-old Japanese female presented with irregular genital bleeding. The biopsy showed an invasive squamous cell carcinoma. Based on the clinical data, the patient was diagnosed as having squamous cervical carcinoma, and radical hysterectomy with ovarian conservation was performed. A diagnosis of cervical LELC was then made by histological methods. An additional examination revealed that the patient was infected with HPV types 16 and 71, but not infected with EBV.

Keywords

Lymphoepithelioma-like carcinoma; Cervix; Epstein-Barr virus; Human papilloma virus; Cervix.

Cite and Share

H. Kyozuka,T. Watanabe,S. Furukawa,S. Soeda,Y. Kiko,K. Fujimori. Lymphoepithelioma-like carcinoma of the uterine cervix: a case report. European Journal of Gynaecological Oncology. 2017. 38(3);459-461.

URL:

https://www.ejgo.net/articles/10.12892/ejgo3499.2017

References

[1] Mills S.E., Austin M.B., Randall M.E.: “Lymphoepithelioma-like carcinoma of the uterine cervix. A distinctive, undifferentiated carcinoma with inflammatory stroma”. Am. J. Surg. Pathol., 1985, 9, 883.

[2] Reich O., Pickel H., Purstner P.: “Exfoloative cytology of a lymphoepithelioma like carcinoma in cervical smear: a case report”. Acta Cytol., 1999, 43, 285.

[3] Iezzoni J., Gaffey M., Weiss L.: “The role of Epstein-Barr virus in lymphoepithelial-like carcinomas”. Am. J. Clin. Pathol., 1995, 103, 308.

[4] Noel J., Lespagnard L., Fayt I., Verhest A., Dargent J.: “Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma like carcinoma of uterine cervix: report of two cases and review of the literature”. Hum. Pathol., 2001, 32, 135.

[5] Walboomers J.M.M., Jacobs M.V., Manos M.M., Bosch F.X., Kummer J.A., Shah K.V., et al.: “Human papillomavirus is a necessary cause of invasive cervical cancer worldwide”. J. Pathol., 1999, 99, 195.

[6] Hamazaki M., Fujita H., Arata T., Takata S., Hamazaki M.: “Medullary carcinoma with lymphoid infiltration of the uterin cervix”. Jpn. J. Cancer Clin., 1968, 14, 787.

[7] Tseng C.J., Pao C.C., Tseng L.H.: “Lymphorpithelioma-like carcinoma of uterine cervix: association with Epstein-Barr virus and human papilloma-virus”. Cancer, 1997, 80, 91.

[8] Hasumi K., Sugano H., Sakamoto G.: “Circumscribe carcinoma of the uterine cervix with marked lymphocytic infiltration”. Cancer, 1977, 39, 2503.

[9] Matias-Guiu X., Komminoth P., Prat J.: “Absence of Epstein-Barr virus DNA from a lymphoepithelioma-like carcinoma of the uterine cervix”. Am. J. Clin. Pathol., 1994, 101, 117.

[10] Saylam K., Anaf V., Fayt I., Noel J.C.: “Lymphoepithelioma-like carcinoma of the cervix with prominent eosinophilic infiltrate: an HPV- 18 associated case”. Acta Obstet. Gynecol. Scand., 2002, 81, 564.

[11] Peyton C.L., Gravitt P.E., Hunt W.C.: “Determinants of genital human papilloma virus detection in a US population”. J. Infect. Dis., 2001, 183, 1554.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top