Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Benign mixed tumor of the vagina
1Department of Pathology, Qingyuan Hospital, Medical College, Jinan University, Qingyuan, Guangdong Province, China
2Department of Pathology, the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong Province, China
3Department of Gynecology and Obstetrics, Tongji Hospital Affiliated to Tongji University, Shanghai, China
Mixed tumor of the vagina is a rare benign tumor containing both epithelial and mesenchymal components. The authors report the case of a 35-year-old woman who presented with a painless mass that had descended from the vagina in the last six months. Physical examination showed the presence of a solitary, non-tender nodule that was 3×3×2 cm in size and seemed to originate from the posterior wall of the lower vagina. The tumor was removed and pathologically examined. The findings were indicative of a mixed tumor of the vagina, and were in agreement with previous cases. No recurrence or progression occurred during the ten-month follow-up. As this tumor shares common features with some other tumors, its differential diagnosis is very important. Moreover, due to the rarity of this disease, gynecologists and pathologists need to familiarize themselves with the features in order to avoid a misdiagnosis.
Vagina; Mixed Tumor; Spindle cell epithelioma.
Y. Song,S.G. Wu,S.N. Dong,F. Luo,K.P. Liu. Benign mixed tumor of the vagina. European Journal of Gynaecological Oncology. 2017. 38(3);465-468.
[1] Kang M.S., Yoon H.K.: “Mixed tumor of the vagina: a case report”. J. Korean Med. Sci., 2002, 17, 845.
[2] Krolls S.O., Boyers R.C.: “Mixed tumors of salivary glands”. Cancer, 1972, 30, 276.
[3] Kaur H., Grover N., Singh S., Sharma P., Sharma S.: “Mixed tumor of parotid cland: a case report”. J. Orofac. Health Sci., 2014, 5, 166.
[4] Diaz N.M., McDivitt R.W., Wick M.R.: “Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases”. Hum. Pathol., 1991, 22, 1206.
[5] Ma C.K., Fine G., Lee M.W., Lewis J.: “Benign mixed tumor of the trachea”. Cancer, 1979, 44, 2260.
[6] Rorat E., Wallach R.C.: “Mixed tumors of the vulva: clinical outcome and pathology”. Int. J. Gynecol. Pathol., 1984, 3, 323.
[7] Brown C.: “Mixed epithelial tumor of the vagina”. Am. J. Clin. Pathol., 1953, 23, 237.
[8] Murdoch F., Sharma R., Al-Nafussi A.: “Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile”. Int. J. Gynecol. Cancer, 2003, 13, 543.
[9] Mahe E., Bishara M., El Demellawy D., DeNardi F., Alowami S.: “The vaginal spindle cell epithelioma: A case report, review of the literature and discussion of potential histogenesis”. Pathol. Res. Pract., 2012, 208, 424.
[10] Sirota R.L., Dickersin G.R., Scully R.E.: “Mixed tumors of the vagina: A clinicopathological analysis of eight cases”. Am. J. Surg. Pathol., 1981, 5, 413.
[11] Skelton H., Smith K.J.: “Spindle cell epithelioma of the vagina shows immunohistochemical staining supporting its origin from a primitive/progenitor cell population”. Arch. Pathol. Lab. Med., 2001, 125, 547.
[12] Malik A., Ratnakar K., Al-Hilal F., Dhaliwal J., El Shafei A.: “Spindle-cell epithelioma: “mixed tumor” of the vagina”. Ann. Saudi Med., 2002, 22, 202.
[13] Oliva E., Gonzalez L., Dionigi A., Young R.H.: “Mixed tumors of the vagina: an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis”. Mod. Pathol., 2004, 17, 1243.
[14] Yogesh K., Amita M., Rajendra K., Raju A., Rekha W., Hemant T.: “Vaginal leiomyoma developing after hysterectomy–case report and literature review”. Aust. N. Z. J. Obstet. Gynaecol., 2005, 45, 96.
[15] Shi Y., Liu Z., Peng Z., Liu H., Yang K., Yao X.: “The diagnosis and treatment of Mullerian adenosarcoma of the uterus”. Aust. N. Z. J. Obstet. Gynaecol., 2008, 48, 596.
[16] Chiang S., Oliva E.: “Cytogenetic and molecular aberrations in endometrial stromal tumors”. Hum. Pathol., 2011, 42, 609.
[17] Wright R., Buntine D., Forbes K.: “Recurrent benign mixed tumor of the vagina”. Gynecol. Oncol., 1991, 40, 84.
Top