Postoperative chemotherapy on placental site trophoblastic tumor in early stage: analysis of 60 cases

Purpose of Investigation: To review the literature of placental site trophoblastic tumor (PSTT) and explore the effect of postoperative chemotherapy in patients with Stage I. Materials and Methods: The authors searched literature on Medline, Excerpta Medica Database (EMBASE), and other resources using the keywords “placental site trophoblastic tumor” and “PSTT” from 1981 to 2014. Results: A total number of 60 patients with Stage I disease were identified, and the presentation, treatment, tumor response, disease status, and follow-up were retrieved and reviewed. According to the authors’ knowledge, 725 cases associated with PSTT have been reported in 29 nations/areas since 1981. In this series, the probability of overall survival at ten years in the group of surgery alone and postoperative chemotherapy were 96.7% and 79.1% (p = 0.199), and recurrence-free survival rates were 91.8% and 63.3%, respectively. Conclusion: The benefit from postoperative chemotherapy is still equivocal. There is a need for scrupulousness before adding postoperative chemotherapy.

Placental site trophoblastic tumor; Gestational trophoblastic neoplasm; Gestational trophoblastic disease; Chemotherapy;Hysterectomy.

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