Article Data

  • Views 676
  • Dowloads 138

Original Research

Open Access

External beam radiotherapy for large genital warts: Does it work?

  • M. Moodley1
  • P.S. Govender2,*,

1Grey’s Hospital / Inkosi Albert Luthuli Central Hospital, Pietermaritzburg, KwaZulu Natal, South Africa

2Inkosi Albert Luthuli Central Hospital, Durban, KwaZulu Natal, South Africa

DOI: 10.12892/ejgo4413.2019 Vol.40,Issue 2,April 2019 pp.275-277

Accepted: 14 September 2017

Published: 10 April 2019

*Corresponding Author(s): P.S. Govender E-mail: poovan@oncocare.co.za

Abstract

Introduction: The management of very large vulval condyloma acuminata is challenging since surgery is associated with significant morbidity. Materials and Methods: Fifty-four patients with very large biopsy-proven vulval warts received external beam radiotherapy. Objective tumour response for target lesions was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria definitions. The retrospective data were analysed by a professional statistician. The data was regarded as purely descriptive. Results: There were 40 patients in whom the size of the genital wart ranged from 10-20 cm. Five patients had warts larger than 20 cm. Fifty-two patients were HIV infected, of which 42 patients had CD4 counts greater than 200 cells/ml and 40 patients were receiving antiretroviral therapy. The majority of patients (n=33) demonstrated a partial response to radiotherapy. There were no patients in whom progressive disease was noted. Both HIV non-infected patients had a complete response to treatment, while 14 of the 52 HIV-infected patients had a complete response to radiotherapy. Thirty-two patients received additional laser or electrocautery for residual lesions. Conclusions: Radiotherapy represents a novel approach for the management of very large vulval warts not amenable to surgical therapy, and has an acceptable side effect profile.

Keywords

Vulval condyloma acuminata; HIV; Genital warts; External beam radiotherapy

Cite and Share

M. Moodley,P.S. Govender. External beam radiotherapy for large genital warts: Does it work?. European Journal of Gynaecological Oncology. 2019. 40(2);275-277.

References

[1] White R., Donnellan S., Leong T.: “Complete resolution of urinary bladder condyloma acuminatum following definitive chemoradiotherapy for anal cancer”. Br. J. Urol. Intl., 2011, 108, 38.

[2] Tytherleigh M.G., Birtle A.J., Cohen C.E., Glynne-Jones R., Liv- ingstone J., Gilbert J.: “Combined surgery and chemotheradiation as a treatment for the Buschke-Lowenstein tumour”. Surgeon, 2006, 4, 378.

[3] Guo C., Guo M.D., Samsen W.: “Noninvasive squamous lesions in the urinary bladder: A clinical analysis of 29 cases”. Am. J. Surg. Path., 2006, 30, 883.

[4] Trombetta L.J., Place R.J. Giant condyloma acuminatum of the anorectum: “Trends in epidemiology and management: report of a case and review of the literature”. Dis. Colon Rectum, 2001, 44, 1878.

[5] Fernandez-Sanchez M., Espinosa-de los Monteros A., Saeb-Lima M., Vergara-Fernandez O.: “Surgical treatment of a perianal giant condyloma acuminate in a HIV patient”. Rev. Gastroenterol. Mex., 2011, 76, 178.

[6] Sobrado C.V.V., Mester M., Nadalin V.V., Nahas S.C., Bocchini S.F., Habr-Gama A.: “Radiation-induced total regression of a highly recurrent giant perianal condyloma: report of a case”. Dis. Colon Rectum, 2000, 43, 257.

[7] Creasman C., Haas P., Fox T., Balzus M.: “Malignant transformation of anorectal giant condyloma accuminatum”. Dis. Colon Rectum, 1989, 32, 481.

[8] Danoff D., Holden S., Thompson R.W., David R.: “New treatment for extensive condylomata acuminata: external radiation therapy”. J. Urol., 1981, 18, 47.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top