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Ovarian tissue cryopreservation and transplantation in a young patient with cervical cancer: the first successful case in Korea

  • S. Lee1
  • J.Y. Song1
  • T. Kim1,*,
  • S.H. Kim2

1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul

2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul (Korea)

DOI: 10.12892/ejgo4564.2019 Vol.40,Issue 3,June 2019 pp.498-501

Published: 10 June 2019

*Corresponding Author(s): T. Kim E-mail: tkim@kumc.or.kr

Abstract

Cytotoxic treatment, such as chemotherapy and/or radiotherapy, can cause severe gonadal damage, resulting in premature ovarian failure and infertility. Fertility preservation plays an important role in the care of young reproductive women with cancer who desire future fertility. Ovarian tissue cryopreservation and transplantation is an effective option to preserve patient fertility and to restore gonadal endocrine function. To the best of the authors’ knowledge, this is the first case of a successful ovarian tissue transplantation after cryopreservation, and recovery of endocrine function for a cervical cancer patient in Korea. In order to provide better treatments for preserving fertility in cancer patients, physicians should recognize and consider many options for fertility preservation and provide timely information and appropriate counseling.

Keywords

Cervical cancer; Ovary; Tissue; Cryopreservation; Transplantation.

Cite and Share

S. Lee,J.Y. Song,T. Kim,S.H. Kim. Ovarian tissue cryopreservation and transplantation in a young patient with cervical cancer: the first successful case in Korea. European Journal of Gynaecological Oncology. 2019. 40(3);498-501.

References

[1] Lee S., Song J.Y., Ku S.Y., Kim S.H., Kim T.: “Fertility preservation in women with cancer”. Clin. Exp. Reprod. Med., 2012, 39, 46.

[2] Lee S., Heytens E., Moy F., Ozkavukcu S., Oktay K.: “Determinants of access to fertility preservation in women with breast cancer”. Fertil. Steril., 2011, 95, 1932.

[3] Loren A.W., Mangu P.B., Beck L.N., Brennan L., Magdalinski A.J., Partridge A.H., et al.: “Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update”. J. Clin. Oncol., 2013, 31, 2500.

[4] Donnez J., Dolmans M.M., Pellicer A., Diaz-Garcia C., Sanchez Serrano M., Schmidt K.T., et al.: “Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation”. Fertil. Steril., 2013, 99, 1503.

[5] Oktay K., Karlikaya G.: “Ovarian function after transplantation of frozen, banked autologous ovarian tissue”. N. Engl. J. Med., 2000, 342, 1919.

[6] Jensen A.K., Macklon K.T., Fedder J., Ernst E., Humaidan P., Andersen C.Y.: “86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children”. J. Assist. Reprod. Genet., 2017, 34, 325.

[7] Herraiz S., Novella-Maestre E., Rodríguez B., Díaz C., Sánchez-Serrano M., Mirabet V., Pellicer A.: “Improving ovarian tissue cryopreservation for oncologic patients: slow freezing versus vitrification, effect of different procedures and devices”. Fertil. Steril., 2014, 101, 775.

[8] Donnez J., Silber S., Andersen C.Y., Demeestere I., Piver P., Meirow D., et al.: “Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live births”. Ann. Med., 2011, 43, 437.

[9] Kim S.S.: “Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site: 10 year longitudinal follow-up study”. J. Assist. Reprod. Genet., 2012, 29, 489.

[10] Wallace W.H., Kelsey T.W., Anderson R.A.: “Ovarian cryopreservation: experimental or established and a cure for the menopause?” Reprod. Biomed. Online, 2012, 25, 93.

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