Article Data

  • Views 860
  • Dowloads 208

Case Reports

Open Access

Cervical villoglandular adenocarcinoma: a rare case report and review of the literature

  • Xibo Liu1,*,
  • Chuanling Hou1

1Department of Pathology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), 312000 Shaoxing, Zhejiang, China

DOI: 10.22514/ejgo.2022.020 Vol.43,Issue 3,June 2022 pp.152-156

Submitted: 27 April 2022 Accepted: 31 May 2022

Published: 15 June 2022

*Corresponding Author(s): Xibo Liu E-mail:


Villoglandular adenocarcinoma (VGA) is a rare variant of cervical adenocarcinoma classified as HPV-associated. We encountered a case of cervical VGA with no evidence of HPV infection reported below. A 50-year-old woman accidentally discovered cervical polyps during gynecological physical examination. After removal, the pathological examination was diagnosed as cervical VGA, and immunohistochemistry showed that p16 was focal positive expression. We reviewed the relevant literature to summarize the clinicopathological features of VGA and the key points of pathological diagnosis and differential diagnosis.


Villoglandular adenocarcinoma; Adult; Female; Humans; Cervix; Pathology

Cite and Share

Xibo Liu,Chuanling Hou. Cervical villoglandular adenocarcinoma: a rare case report and review of the literature. European Journal of Gynaecological Oncology. 2022. 43(3);152-156.


[1] Young RH, Scully RE. Villoglandular papillary adenocarcinoma of the uterine cervix. A clinicopathologic analysis of 13 cases. Cancer. 1989; 63: 1773–1779.

[2] McCluggage WG, Singh N, Gilks CB. Key changes to the world health organization (WHO) classification of female genital tumours introduced in the 5th edition (2020) histopathology. 2022; 80: 762–778.

[3] Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, et al. International endocervical adenocarcinoma criteria and classification (IECC). American Journal of Surgical Pathology. 2018; 42: 214–226.

[4] Turashvili G, Park KJ. Cervical glandular neoplasia. Surgical Pathology Clinics. 2019; 12: 281–313.

[5] Heatley MK. Villoglandular adenocarcinoma of the uterine cervix? A systematic review of the literature. Histopathology. 2007; 51: 268–269.

[6] Korach J, Machtinger R, Perri T, Vicus D, Segal J, Fridman E, et al. Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge. Acta Obstetricia et Gynecologica Scandinavica. 2009; 88: 355–358.

[7] Zhang Y, Wang Y, Liu Y, Yang J, Liu C. A retrospective study and literature review of cervical villoglandular adenocarcinoma: a candidate paradigm of silva system pattern A. Applied Immunohistochemistry & Molecular Morphology. 2021; 29: 467–472.

[8] Alfsen GC, Reed W, Abeler VM. Reproducibility of classification in non-squamous cell carcinomas of the uterine cervix. Gynecologic Oncology. 2003; 90: 282–289.

[9] Zhao L, Xu T, Cui M, Fu Z. A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. Oncology Letters. 2016; 11: 2164–2168.

[10] Young RH, Clement PB. Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis. Histopathology. 2002; 41: 185–207.

[11] Shen H, Huang Z, Zhang S, Zhang Y, An J, Luo J, et al. The clinicopathologic and immunohistochemical features of villoglandular adenocarcinoma of uterine cervix. Indian Journal of Pathology and Microbiology. 2018; 61: 549.

[12] Guo P, Liu P, Yang J, Ren T, Xiang Y. Villoglandular adenocarcinoma of cervix: Pathologic features, clinical management, and outcome. Cancer Management and Research. 2018; 10: 3955–3961.

[13] McCluggage WG. Progress in the pathological arena of gynecological cancers. International Journal of Gynecology & Obstetrics. 2021; 155: 107–114.

[14] Ren H, Almadani N, Pors J, Leung S, Ho J, Chow C, et al. International endocervical adenocarcinoma criteria and classification (IECC): an independent cohort with clinical and molecular findings. International Journal of Gynecological Pathology. 2021; 40: 533–540.

[15] Stolnicu S, Hoang L, Soslow RA. Recent advances in invasive adenocarcinoma of the cervix. Virchows Archiv. 2019; 475: 537–549.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time