Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer

Purpose of Investigation: To investigate concordance between grades determined by endometrial sampling and final pathology, and factors affecting this concordance, in endometrioid type endometrial cancer. Materials and Methods: In this retrospective study, 330 endometrioid type endometrial cancer patients were enrolled. For evaluating the concordance between histological grades in preoperative and postoperative pathology reports, Kappa statistic and comparative analyses were performed. Results: In 230 of 330 (69.7%) patients, the endometrial sampling-determined grade was in concordance with the final histological grade. The concordance was minimal according to the Kappa statistic in all patients (K = 0.390; 95% confidence interval = 0.666-0.047; p < 0.01). There was no significant correlation between diabetes mellitus, cancer antigen (Ca) 125, and Ca 19-9 status, and grade concordance (p = 0.86, p = 0.715, p = 0.774, respectively). Conclusion: In endometrioid type endometrial cancer, concordance between preoperative and postoperative histological grades was minimal. Therefore, histological grading by preoperative sampling alone is insufficient for decisionmaking in pelvic lymphadenectomy.

Dilatation and curettage; Endometrial neoplasms; Endometrium; Biopsy

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