RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo201102141
T1  - Prognosis and role of postmastectomy radiotherapy in patients with T1-T2 breast cancer with one to three positive axillary nodes
A1  - Z. Chen
A1  - J. Hao
A1  - H. Zhuang
A1  - J. Yu
K1  - Postmastectomy radiotherapy; Breast cancer; Positive axillary nodes
YR  - 2011
SP  - 141
AB  - <p><i>Purpose: </i>To evaluate the prognosis and role of postmastectomy radiotherapy (PMRT) in T1-T2 breast cancer with one to three positive axillary nodes. <i>Methods: </i>The 10-year Kaplan-Meier locoregional recurrence (LRR), distant recurrence (DR), disease-free survival (DFS) and overall survival (OS) were compared between the NO and 1-3N+ cohorts. The role of PMRT was evaluated in the 1-3N+ cohort. <i>Results:</i> The 10-year LRR, DR, DFS, OS rates in NO and the 1-3N+ cohorts were as follows: LRR 7.5% vs 19.4% (<i>p</i> = 0.011); DR 14.4% vs 23.0% (<i>p</i> = 0.029); DFS 71.3% vs 51.2% (<i>p</i> = 0.001) and OS 77.0% vs 58.7% (<i>p</i> = 0.001). Of the 192 1-3N+ patients not treated and treated with PMRT, the outcomes were: LRR 20.1% vs 18.4% (<i>p</i> = 0.047); DR 26.4% vs 21.5% (<i>p</i> = 0.743); DFS 40.2% vs 55.4% (<i>p</i> = 0.260) and OS 40.7% vs 66.0% (<i>p</i> = 0.344), respectively. <i>Conclusion: </i>PMRT reduces the 10-year LRR rate for such patients, but further examination is needed.</p>