RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo201102146
T1  - Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer
A1  - S. Nishimura
A1  - H. Tsuda
A1  - H. Nomura
A1  - F. Kataoka
A1  - T. Chiyoda
A1  - H. Tanaka
A1  - K. Tanaka
A1  - N. Susumu
A1  - D. Aoki
K1  - Endometrial cancer; Cervical cancer; Adenocarcinoma; HIG2
YR  - 2011
SP  - 146
AB  - <p>For both cervical cancer (UCC) and endometrial cancer (EMC) there are no effective prognostic markers. In this study, we evaluated HIG2 protein expression in 332 uterine cancers (186 UCCs and 146 EMCs) and examined the relationship between HIG2 protein expression and clinical factors, including prognosis. Totally, HIG2 expression was detected in 58% of UCC and 66% of EMC. However, there was no significant relationship between HIG2 expression and age, clinical stage and histology in either UCC or EMC. In addition, HIG2 protein expression was not related to prognosis of UCC or EMC. The positivity rate of HIG2 protein was 56% and 61% in early-stage UCC and EMC, respectively and 67% in non-squamous cell carcinoma of UCC. The positivity rate of HIG2 protein was high even in early-stage UCC and EMC</p>