RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo201102164
T1  - Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervicalintraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP)
A1  - H.Y. Guo
A1  - Y.L. Guo
A1  - K. You
A1  - L. Geng
K1  - Loop electrosurgical excisional procedure; Human papillomavirus; Follow-up
YR  - 2011
SP  - 164
AB  - <p><i>Purpose: </i>The purpose of this study was to follow-up cervical intraepithelial neoplasia grades 2 or 3 (CIN2/3) cases after a loop electrosurgical excisional procedure (LEEP) by liquid-based cytology (LBC) and detection of HPV DNA. <i>Methods:</i> LEEP was performed for the first diagnosed CIN2/3 cases. Six and 12 months after LEEP, LBC and HPV DNA detection were performed. <i>Results:</i> The number of cases with CIN2 accounted for 64.5% (60/93) of the total cases before LEEP. Six months post LEEP, the number of cases with normal LBC and negative HPV DNA accounted for 63.4% (59/93). Cases with abnormal LBC accounted for 17.2 (16/93), and cases with persistent positive HPV DNA accounted for 11.8% (7/93). Two cases had both persistent positive HPV DNA and abnormal LBC. A vaginal intraepithelial neoplasm (VAIN2) was found in one of the HPV DNA persistent positive cases. Twelve months post LEEP, 4.3% (8/93) of the cases were HPV DNA positive. Abnormal LBC was observed in four cases (of which 2 cases were HPV DNA positive) with normal LBC and negative HPV DNA at six months post LEEP. <i>Conclusion: </i>HPV DNA examination is instrumental for the detection of VAIN.</p>