RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo201103274
T1  - XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
A1  - G. Barbisan
A1  - L.O. Pérez
A1  - L. Difranza
A1  - C.J. Fernández
A1  - N.E. Ciancio
A1  - C.D. Golijow
K1  - Cervical Cancer; HPV; Single Nucleotide Polymorphisms; XRCC1
YR  - 2011
SP  - 274
AB  - <p><i>Background:</i> XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. <i>Materials and methods:</i> We conducted a case-control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. <i>Results: </i>Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associated with a decreased risk for cervical carcinoma. <i>Conclusion: </i>Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.</p>