RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo2566.2015
T1  - Sentinel node mapping with radiotracer alone in vulvar cancer: a five year single-centre experience and literature review
A1  - S. Bogliolo
A1  - P. Marchiole
A1  - P. Sala
A1  - E. Giardina
A1  - G. Villa
A1  - E. Fulcheri
A1  - M. Valenzano Menada
K1  - Vulvar cancer; Sentinel-node biopsy; Squamous cells carcinoma; Radiotracer; Groin dissection.
YR  - 2015
SP  - 10
AB  - <p><i>Purpose of investigation: </i>The pathologic status of lymph node represents the most important prognostic factor in vulvar cancer patients, but a complete groin dissection is associated with high post-operative morbidity. Sentinel lymph node (SLN) could be representative of the totality of regional lymph nodes and consequently its biopsy might have a significant impact on clinical management in vulvar cancer patients. <i>Materials and Methods: </i>From January 2006 to December 2010 45 patients with vulvar carcinoma are evaluated. Preoperative lymphatic mapping with technetium–99m–labeled nanocolloid was performed in all patients, followed by radioguided intraoperative detection. The detection rate is 100% of patients. All the SLNs were dissected separately for histopathological evaluation and a routine inguinofemoral lymphadenectomy was performed. <i>Results: </i>Nine patients had positive SLNs. In the remaining 36 patients with negative SLNs, one of them showed positive non-SLNs at histological examination. It was the only false negative case in the present series. <i>Conclusions: </i>Based on literature review, lymphoscintigraphy and sentinel node biopsy under gamma-detecting probe guidance offer a reliable and careful method to identify sentinel node in early vulvar cancer. Taking certain guidelines, SLN biopsy seems to be a safe alternative to inguinofemoral node dissection in order to reduce morbidity of surgical treatment.</p>