RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3139.2016
T1  - Comparison of p57, c-erbB-2, CD117, and Bcl-2 expression in the differential diagnosis of hydatidiform mole and hydropic abortion
A1  - O. Erol
A1  - D. Suren
A1  - B. Tutus
A1  - K. Yararbas
A1  - A. Sayiner
A1  - M.K. Ozel
A1  - A.U. Derbent
A1  - C. Sezer
K1  - Bcl-2; CD117; c-erbB-2; Hydatidiform mole; p57.
YR  - 2016
SP  - 522
AB  - <p><i>Purpose: </i>To explore the utility of p57, c-erbB-2, CD117, and Bcl-2 immunostaining in the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA). <i>Materials and Methods: </i>Immunohistochemical expression of the p57, c-erbB-2, CD117, and Bcl-2 proteins were investigated semi-quantitatively using paraffin-embedded tissue sections from histologically unequivocal cases of CHM (n = 20), PHM (n = 23), and HA (n = 17). <i>Results: </i>All cases of CHM exhibited a striking absence of p57 expression. The percentage of positive p57 staining was similar between PHMs (73.9%) and HAs (76.5%) (<i>p </i>&gt; 0.05). The comparison of c-erbB-2 expression revealed a significantly higher percentage of positive c-erbB-2 staining in CHMs (45%) compared with that in PHMs (8.7%) and HAs (5.9%) (<i>p </i>= 0.006 and 0.01, respectively). The CD117 expression pattern (immunoreactivity score, percentage of positive cells, and staining intensity) was significantly lower in HAs compared with that in PHMs and CHMs (<i>p </i>&lt; 0.05 for all). A significantly increased Bcl-2 expression pattern was observed in HAs compared with that in PHMs and CHMs (<i>p </i>&lt; 0.05 for all). <i>Conclusion: </i>Immunohistochemical examination of p57, c-erbB-2, CD117, and Bcl-2 expression represents a relatively simple, reliable, and cost-efficient procedure to definitively distinguish among CHM, PHM, and HA.</p>