RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3149.2016
T1  - Growing teratoma syndrome: an unusual evolution of treated ovarian immature teratoma - a case report
A1  - A. Gómez-Portilla
A1  - R. Bustamante
A1  - E. López de Heredia
A1  - L.I. Lete
A1  - M. Cuadra
A1  - S. Domínguez
K1  - Growing teratoma syndrome; Germ cell tumors; Immature teratoma; Chemotherapeutic retroconversion; Ovarian neoplasms.
YR  - 2016
SP  - 729
AB  - <p>Growing teratoma syndrome (GTS) is a rare condition among germ cell tumor (GCT) patients during treatment with systemic chemotherapy. It is characterized by the development of enlarging masses, the normalization of tumor markers, and the presence of only mature teratoma in the pathological specimen. The authors present the unusual case of a 15-year-old girl with an immature teratoma treated with conventional surgery and systemic chemotherapy. On her follow up, although tumor markers returned to normal, there was an enlargement of abdomino-pelvic masses confirmed by a PET/TC study. With the diagnosis of a GTS, the patient underwent a complete cytoreduction. Histologically, all the specimens contained mature teratoma tissue. The patient remains clear with no signs of recurrence with no further treatment. The knowledge and awareness of this syndrome are highlighted in order to prevent further unnecessary chemotherapy and allow an optimal cytoreduction, which seems to be the most effective therapy so far</p>