RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3271.2016
T1  - The ovarian cancers in geriatric population: the validity of inflammatory markers, malignancy risk indices 1, 2, 3, 4, and CA-125 levels in malignancy discrimination of adnexal masses
A1  - F. Vural
A1  - N. Aka
A1  - S. Ertaş
A1  - G. Köse
A1  - E.C. Tüfekçi
K1  - Ovarian cancers; Risk of malignancy risk index; Adnexal masses; CA-125; cancer screening; Neutrophil lymphocyte ratio; Platelet lymphocyte ratio; Geriatric; Menopause.
YR  - 2016
SP  - 846
AB  - <p><i>Purpose: </i>To investigate the predictive value of the Risk of Malignancy Index (RMI), CA-125, and inflammatory markers in discriminating ovarian cancers (OCs). <i>Materials and Methods: </i>The postmenopausal (PM) women (n = 139) with adnexal masses who underwent surgery were included. The predictive value of CA-125, RMI (1, 2, 3, and 4) and inflammatory markers [neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR)] were calculated in geriatric (G) and non-geriatric women. <i>Results: </i>OCs had significantly increased NLR and PLR. RMI models were highly reliable in PM (Kappa: 0.642-0.715; AUC: 0.907-0.934). CA-125 measurement alone had good accuracy and moderate reliability in PM (kappa: 0.507-0.587), excellent accuracy and moderate reliability in G, NLR, and PLR predicting OCs, showed fair agreement in the PM, while PLR had a moderate agreement with G. <i>Conclusion: </i>RMI algorithms were the best models for malignancy prediction. However, the rise of PLR and CA-125 levels in a G population may be used as referring adnexal masses to gynecologic oncologists.</p><p><br></p>