RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3370.2017
T1  - Expression of topoisomerase II, BCL-2, and Ki-67 in ovarian cancer tissue and their effects on the development and prognosis of ovarian cancers
A1  - E.N. Akyurek
A1  - A.F. Yavuz Avsar
A1  - U.M. Ural
A1  - A. Kilicarslan
A1  - M. Yildirim
K1  - Ovarian cancer; Topoisomerase II; Bcl-2; Ki-67; Cancer tissue.
YR  - 2017
SP  - 675
AB  - <p><i>Purpose: </i>The objective of this study was to evaluate the role of the expression of topoisomerase II, BCL-2, and Ki-67 in an ovarian tissue and their effects on the development and the prognosis of ovarian cancers. <i>Materials and Methods: </i>The study consisted of 38 female patients with ovarian cancers. Patients' characteristics, tumor type, stage, and the grade of the disease, and topoisomerase II, Bcl-2, and Ki-67 values in ovarian tissue were compared. <i>Results: </i>Extensivenesses of topoisomerase II and Ki-67 staining in early-stage disease were found statistically different from those in the advanced stage diseases (for topoisomerase II, 60.38 ± 33.87% <i>vs </i>85 ± 8.5%, <i>p </i>= 0.017, for Ki-67; 25.07 ± 25.04% <i>vs </i>51±25.29%, <i>p </i>= 0.012). Differences of Bcl-2 staining between two groups were not significant (30.38 ± 38.82 % <i>vs </i>18.2 ± 30.58%, <i>p </i>= 0.377). <i>Conclusions: </i>Expressions of topoisomerase II and Ki-67 in ovarian cancer tissues were associated with advanced stage diseases and expression of Bcl-2 refers to good histological grade in patients.</p>