RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo340208
T1  - Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer
A1  - M. J. Song
A1  - S. H. Lee
A1  - M. R. Choi
A1  - H. J. Son
A1  - C. W. Lee
A1  - J. H. Yoon
A1  - Y. G. Park
A1  - S. Y. Hur
A1  - K. S. Ryu
A1  - J. M. Lee
K1  - Advanced ovarian cancer
K1  - CA-125; Early detection of recurrence.
YR  - 2013
SP  - 148
AB  - <p></p><p>Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in
this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with
other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among
the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8
had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p &lt; 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as
a predictor of recurrent advanced ovarian cancer.</p>