RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3470.2017
T1  - Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study
A1  - N.H. Abdel-Hay
A1  - A.A. Mansour
A1  - M.A. El Sherbini
A1  - F.I. Abdel Motaleb
A1  - A.H. El-Shalakany
K1  - Ovarian tumor; q-RT-PCR; FoxP3 mRNA; CA125; Treg.
YR  - 2017
SP  - 251
AB  - <p><i>Purpose: </i>To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. <i>Materials and Methods: </i>Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA125 and risk of malignancy index (RMI). <i>Results: </i>FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate: 15/25 <i>vs</i>. 10/25; <i>p </i>= 0.157, median: 0.429 <i>vs</i>. 0.046; <i>p </i>= 0.684, and mean ± SD: 73.75 ± 234.68 <i>vs</i>. 247.09 ± 792.17; <i>p </i>= 0.301. Although it showed much less diagnostic performance (AUC: 0.534), FoxP3 mRNA enhanced the diagnostic sensitivity and specificity of both CA125 and RMI (96% and 100%, for both). <i>Conclusion: </i>FoxP3 mRNA may not be good diagnostic marker in ovarian tumors; however it may prove valuable in defining underlying tumor molecular signature.</p>