RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3927.2018
T1  - Impacts of Fuzhengxiaoyan decoction on immune functions in nude mice bearing EMT-6 breast cancer
A1  - Kuanyu Wang
A1  - Jing Chen
A1  - Kejun Zhao
A1  - Guiyun Jiang
A1  - Xiaolong Sun
K1  - Fuzhengxiaoyan decoction; Spleen index; Thymus index; IL-6; TGF-β.
YR  - 2018
SP  - 133
AB  - <p>Objective: The aim of this study was to observe the impacts of Fuzhengxiaoyan decoction (FZXY) on the immune functions in nude mice bearing EMT-6 breast cancer (EMT-6-carryring mice). Materials and Methods: The successfully prepared EMT-6 breast cancerbearing nude mice models were randomly divided into three groups (n=20): the treatment group: orally administrated FZXY, the control group: orally administrated the Shenmai injection, and the model group: orally administrated an equal volume of normal saline, twice a day for consecutive 14 days. Results: The mice in each group were then sacrificed and their spleen and thymus indexes were compared; ELISA was performed to detect the content changes of TGF-β and IL-6 in the spleens. FZXY could significantly increase the  spleen and thymus indexes in these EMT-6-carrying mice when compared with the model group (p &lt; 0.05); meanwhile, the contents of IL-6 and TGF-β in the spleens of the FZXY group were significantly decreased (p &lt; 0.05), similar to those in the positive control group (Shenmai injection). Conclusion: FZXY could improve the immune functions of EMT-6- bearing mice, which was the mechanism of this prescription towards inhibiting breast cancer.</p>