RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo3962.2018
T1  - Significance and expression of c-erBb-2, p53, and caspase-3 in breast cancer tissue in different age groups
A1  - Z.Y. Liu
A1  - L. Guo
A1  - G. Xiao
A1  - G.Y. Dong
A1  - Y.X. Zhang
A1  - H. Cheng
A1  - X.Y. Wang
A1  - C. Yang
K1  - Breast cancer; Apoptotic factor; Immunohistochemical assay; Prognosis.
YR  - 2018
SP  - 430
AB  - <p>Objective: The aim of this study was to explore the expression of c-erBb-2, p53, and caspase-3 in breast cancer tissue in different age groups. Materials and Methods: One hundred seventy-two patients with breast cancer were divided into two groups by age (≤ 35 and ≥ 40 years). Immunohistochemical analysis was performed to detect the expression of c-erBb-2, p53, and caspase-3 in the tumor tissue from the patients. The authors compared the expression levels between the two groups. Results: In 90 young women with breast cancer, the positive expression rate of c-erBb-2, p53, and caspase-3 was 41.1% (37/90), 67.8% (61/90), and 35.6% (32/90), respectively, and it was 23.2% (19/82), 40.8% (39/82), and 57.3% (47/82), respectively, in the older patients. In the young group, the expression of caspase-3 was significantly lower (p &lt; 0.05) and the expression of c-erbB-2 and p53 were significantly higher (p &lt; 0.01). Conclusion: The biological behavior of breast cancer and apoptosis is associated with the expression of p53 and c-erbB-2; thus, more attention should be paid to the expression of cell apoptotic factors when treating and assessing the prognosis of patients with breast cancer.</p>