RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo4121.2018
T1  - Concentration of serotonin in perimenopausal women with ductal breast cancer and polycystic ovary syndrome
A1  - S. Stanosz
A1  - J. von Mach Szczypiński
A1  - A. Fogel
A1  - E. Sowińska-Przepiera
A1  - J. Kościuszkiewicz
A1  - E. Żochowska
A1  - A. Syrenicz
K1  - Serotonin; Sex hormones; Breast cancer; Menopause; Polycystic ovary syndrome.
YR  - 2018
SP  - 884
AB  - <p><i>Purpose of Investigation: </i>To analyze a relationship between histological grade of ductal breast cancer (BC) and intratumor concentration of serotonin in women with polycystic ovarian syndrome (PCOS), and to study the long-term effects of innovative neurohormonal therapy in this group. <i>Materials and Methods: </i>The study included 65 women (28 premenopausal and 37 postmenopausal, age 43-69 years) with PCOS and BC. Aside from mastectomy, chemotherapy and menopausal status-specific hormonal treatment, all subjects received metformin, quinagolide, melatonin, and methysergide maleate. Serum concentrations of sex hormones were determined post-mastectomy and after five and ten years. <i>Results: </i>Intratumoral concentrations of serotonin in grade II and III BC were higher than in grade I tumors. After ten years, all subjects had normal concentrations of estrogens, prolactin, and serotonin, and showed no signs of BC recurrence. <i>Conclusion: </i>Intratumor level of serotonin may serve as a marker of BC aggressiveness. Neurohormonal therapy may prevent progression of BC.</p>