RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo4343.2019
T1  - The effect of different cervical transformation zone types on the colposcopic diagnosis of cervical intraepithelial neoplasia
A1  - Aiping Fan
A1  - Chen Wang
A1  - Liqin Zhang
A1  - Ye Yan
A1  - Yingmei Wang
A1  - Cha Han
A1  - Fengxia Xue
K1  - Cervical intraepithelial neoplasia;
Colposcopically directed biopsy; Colposcopy; Squamous intraepithelial lesions
of the cervix; Transformation zone
YR  - 2019
SP  - 290
AB  - <p><i>Purpose:</i> To analyze the effects of cervical transformation zone (TZ) on the colposcopic diagnosis of cervical intraepithelial neoplasia (CIN). <i>Materials and Methods:</i> The authors retrospectively evaluated 482 patients who underwent conizaion between September 2012 and September 2016. The cytology, colposcopic impressions and histological diagnoses from biopsy and cone specimens were compared. <i>Results:</i> An agreement of 88.1% was observed between high-grade cytology and final histological diagnoses among the three TZ types. Significant differences between the colposcopic impressions and final histological diagnoses were observed for TZ types 1 and 2 <i>vs.</i> type 3. The overall agreement was 89.1% regarding the histology findings on colposcopically directed biopsy (CDB) and cone specimens, which correlated significantly with TZ (<i>p</i> = 0.004) and the number of cervical biopsies (<i>p</i> = 0.032). The agreement between histology results on endocervical curettage (ECC) and the final histology results was 28.24% in the patients with TZ type 3. <i>Conclusions:</i> Cervical TZ types variably influence colposcopically diagnostic accuracy for CIN, and TZ type 3 was associated with the lowest accuracy.</p>