RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo4640.2019
T1  - The hr-HPV based cervical cancer screening: results of a  four-years experience in a single screening center of Italy
A1  - C. Chiappetta
A1  - C. Puggioni
A1  - E. Lendaro
A1  - J. Cacciotti
A1  - G. Migliore
A1  - P. Bellardini
A1  - V. Petrozza
A1  - C. Della Rocca
A1  - C. Di Cristofano
K1  - Human papillomavirus; Cervical cancer; Screening; hr-HPV test; Pap test.
YR  - 2019
SP  - 932
AB  - <p>Purpose of Investigation: The study was performed to evaluate four years of experience (2012-2015) in high risk-human papillo-mavirus (hr-HPV) testing in the cervical cancer screening in Latina (Italy). Materials and Methods: The hr-HPV as primary test is per-formed only on women aged 35-64, followed by a Pap test as triage, while women aged 25-34 are invited to perform only a Pap test. Results: Women resulted positive to hr-HPV test and positive to Pap test were 5.6% and 4.1%, respectively. Among women aged 25-34, the hr-HPV test was used as triage for women with atypical squamous cells of undetermined significance (ASCUS) and 69.9% resulted positive to the test. The positive predictive value (PPV) for high cervical intraepithelial lesions (HSIL) was higher in women aged 35-64 (9.9% vs. 6.9%), while the detection rate (DR) for HSIL was higher in young women (2.4‰ vs. 1.2‰). The authors found that 52.5%of women with hr-HPV+/Pap test resulted with hr-HPV+ at one-year recall and the DR for HSIL lesions of this population was very low (0.27‰). Discussion: The present  data confirms that the application of hr-HPV test showed elevated performance in cervical cancer screening and that the application of hr-HPV test in managing ASCUS leads to a decreased use of inappropriate colposcopies. Finally, it may be useful to extend the period of follow-up for women hr-HPV+/Pap test to reduce unnecessary colposcopies.</p>