RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo4817.2019
T1  - A case of placental site trophoblastic tumor and a retrospective analysis
A1  - Yangyang Shi
A1  - Yongyun Shi
A1  - Dabao Wu
K1  - Placental site trophoblastic tumor; Hysterectomy; Pathology; Immunohistochemistry; Chemotherapy.
YR  - 2019
SP  - 1096
AB  - <p>Placental site trophoblastic tumor (PSTT) refers to intermediates derived from intermediate trophoblasts, a particular type of tro-phoblastic tumor from the placenta site (gestational trophoblastic disease, GTD), whose pathological morphology and biological be-haviors and other trophoblastic tumors are very different. Here, the authors report one case of PSTT, which is from the Anhui Provincial Hospital Affiliated to Anhui Medical University. A 39-year-old woman presented with  abnormal uterine bleeding for four months after she had an abortion. She underwent curettage surgery in a local hospital, revealing a pathology of choriocarcinoma. Methotrexate (MTX) chemotherapy was ineffective, and blood hCG continued to rise,while in this hospital ultrasonographic examination the bottom of the uterus exhibited a uneven echo, with ill-defined and unclear intrauterine boundaries and a “honeycomb” structure in the serosa. After hysterectomy ,pathology revealed a bottom PSTT with invasion of the muscle which was greater than 50%. Microscopically, the tumor consists of sheets of intermediate trophoblastic cells invading the myometrium. Immunohistochemistry showed positive results for PCK, inhibin, hPL, and β-HCG (spotty +). A course of combined EMA-CO chemotherapy was performed ten days after the surgery, and the patient was then discharged after reviewing the normal indicators.The patient was followed for 36 months without recurrence.</p>