RT  - European Journal of Gynaecological Oncology
ID  - 10.12892/ejgo5152.2019
T1  - A case of metastatic mixed trophoblastic tumor
A1  - E. Kertowidjojo
A1  - O. Taha
A1  - M. Pearl
A1  - R. Batiste
A1  - A. Kudelka
K1  - Metastatic mixed trophoblastic tumor (MTT); Choriocarcinoma (CC); Epithelioid trophoblastic tumor (ETT).
YR  - 2019
SP  - 1024
AB  - <p>The authors present a case report of a patient with metastatic mixed trophoblastic tumor (MTT) comprised of choriocarcinoma (CC) and epithelioid trophoblastic tumor (ETT) with pulmonary metastases at presentation. The patient underwent surgical management fol-lowed by high-dose methotrexate EMA-EP (etoposide, methotrexate, and actinomycin-D - etoposide and cisplatin). Though the patient initially responded well to the therapy regimen, she eventually developed brain metastases, which were morphologically consistent with ETT. The authors conclude that while chemotherapy is likely effective against the CC component, the ETT component of the tumor remains relatively chemoresistant and continued to progress throughout her therapy. This case illustrates the difficulty in treating MTTs and a need for further studies and general guidelines.</p>