Endometrial cancer (EC) is a prevalent type of malignancy, highlighting the need for the development of effective therapies and the identification of novel therapeutic targets. FOXK2, a member of the Foxhead box (FOX) family, has been implicated in cancer progression. However, the role of FOXK2 in EC and its underlying mechanisms remain poorly understood. This study investigates the function of FOXK2 in EC. FOXK2 is significantly overexpressed in EC tissues. Knockdown of FOXK2 impedes the proliferation of EC cells and inhibits their motility and epithelial-mesenchymal transition (EMT). Mechanistically, FOXK2 depletion disrupts EC progression by targeting Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In conclusion, FOXK2 regulates EC cell progression through modulation of ZEB1.