RT  - European Journal of Gynaecological Oncology
ID  - 10.31083/j.ejgo.2021.03.2343
T1  - Clinical characteristics and prognostic outcomes of gynaecological multiple primary malignant neoplasms
A1  - Ying Sun
A1  - Yi Jiang
A1  - Juveria Rahman
A1  - Xing Chen
A1  - Xiong Yuan
A1  - Jinhui Liu
A1  - Huihua Dai
A1  - Wenjun Cheng
K1  - Gynaecological cancer; Multiple primary
malignant neoplasms (MPMN); Breast cancer
YR  - 2021
SP  - 457
AB  - <p><i>Objective</i>: To investigate the clinical characteristics and the prognostic outcomes of patients with gynaecological multiple primary malignant neoplasms (MPMN). <i>Materials and methods</i>: For a period of ten years, from January 2008 to December 2018, patients with gynaecological MPMN were enrolled for this study. The clinical characteristics and survival outcomes were collected and analyzed. <i>Results</i>: A total of 126 patients with gynaecological MPMN were included, comprising 15 synchronous MPMN and 111 metachronous MPMN. The average age of the patients with gynaecological MPMN was 57.6 <inline-formula>±<math><mo>±</mo></math></inline-formula> 10.8 years, and the probability of overall survival (OS) at 1, 2, 3, and 5 years was 88.6%, 82.6%, 76.9% and 68.7%, respectively. The OS of patients with gynaecological cancer as the first neoplasm was worse than those with non-gynaecological cancer as the first neoplasm (HR: 2.2, <i>P </i>= 0.049); the OS of patients accompanied by breast cancer was better than those accompanied by other cancers (HR: 0.346, <i>P </i>= 0.033). Univariate regression analysis showed that “age”, “FIGO stage” and “gynaecological cancer as the first neoplasm” were the factors for poor survival; “Accompanied by breast cancer” and “surgery for first or second neoplasm” were the factors for favourable survival. <i>Conclusions</i>: “Gynaecological cancer as the first neoplasm” is a factor for poor survival in patients with gynaecological MPMN, and “FIGO stage” is the independent risk factor (HR: 2.339, <i>P </i>= 0.001). “Accompanied by breast cancer” and “surgery for the neoplasm” are factors for favourable survival. Mostly, “surgery for the second neoplasm” was the independent protective factor (HR: 0.212, <i>P </i>= 0.005) for gynaecological MPMN.</p>