RT  - European Journal of Gynaecological Oncology
ID  - 10.31083/j.ejgo4204117
T1  - The Ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer
A1  - Erdem Cubukcu
A1  - Ahmet Bilgehan Sahin
A1  - Fatma Oz Atalay
A1  - Birol Ocak
A1  - Mine Ozsen
A1  - Candan Demiroz Abakay
A1  - Kemal Ozerkan
A1  - Ulviyya Hasanzade
A1  - Merve Mesohorli
A1  - Adem Deligonul
A1  - Hakan Ozan
A1  - Turkkan Evrensel
K1  - Endometrial cancer; Low-risk; Ki-67; NLR; Survival
YR  - 2021
SP  - 775
AB  - <p><i>Objective</i>: To investigate the prognostic factors comparing clinical, histopathological, and laboratory parameters in low-risk endometrial cancer (EC). <i>Methods</i>: In the present single-center study, multivariate Cox regression analysis was performed on retrospective clinical and laboratory data and histopathological features obtained from the re-evaluation of 253 patients with low-risk EC. Receiver operating characteristic curves (ROC) were plotted for neutrophile-lymphocyte ratio (NLR), platelet-lymphocyte ratio, lymphocyte-monocyte ratio and Ki-67 index for recurrence. Kaplan-Meier analysis was employed for survival rates. <i>Results</i>: The median age was 58.5 years (32.0–75.4). Most of the patients were obese and post-menopausal. In nearly half of the patients, lymphadenectomy was performed in addition to hysterectomy and oophorectomy. The median tumor size was 30 mm (range 2–80), and the median Ki-67 index was 25 (1–90). According to the ROC curve analysis, the cut-off values for the Ki-67 index, NLR, PLR, and LMR were determined as <inline-formula><math><mo>≥</mo></math></inline-formula>22, <inline-formula><math><mo>≥</mo></math></inline-formula>1.98, <inline-formula><math><mo>≥</mo></math></inline-formula>115.3, and <inline-formula><math><mo>≤</mo></math></inline-formula>4.71, respectively. The log-rank test revealed that the patients with a Ki-67 index lower than 22% and NLR lower than 1.98 had statistically longer recurrence-free survival (RFS) (<i>p</i> = 0.002 for Ki-67 index and <i>p</i> = 0.004 for NLR). The multivariate analysis revealed that the Ki-67 index and NLR were statistically significant factors for RFS (<i>p</i> = 0.012 and <i>p</i> = 0.029, respectively). <i>Conclusion</i>: The present study highlights the prognostic implications of both the Ki-67 index and NLR in low-risk EC.</p><p><br></p>