RT  - European Journal of Gynaecological Oncology
ID  - 10.31083/j.ejgo4204119
T1  - Association of the rs2430561 polymorphism of the interferon-γ gene with cervical cancer susceptibility and prognosis in Han Chinese women
A1  - Heng Wei
A1  - Yang Zhang
A1  - Qiao Zhang
A1  - Yanming Lu
A1  - Yunlong Huo
A1  - Ning Wang
K1  - Cervical cancer; Single nucleotide polymorphism; Genetic susceptibility; IFN-γ
YR  - 2021
SP  - 788
AB  - <p><i>Objectives</i>: To investigate IFN-<inline-formula><math><mi>γ</mi></math></inline-formula> rs2430561 polymorphisms in Han women in northeast China and the relationship between the rs2430561 polymorphisms and the risk of cervical cancer. <i>Methods</i>: PCR-ASP was used for genotyping. IFN-<inline-formula><math><mi>γ</mi></math></inline-formula> rs2430561 polymorphism was detected in 173 cases of cervical invasive carcinoma and 422 healthy controls in Han women in northeast China. <i>Results</i>: The allele and genotype distributions of the IFN-<inline-formula><math><mi>γ</mi></math></inline-formula> rs2430561 polymorphism were not significantly different between each of the groups (<i>P </i><inline-formula><math><mo>&gt;</mo></math></inline-formula> 0.05). There was no significant relationship between rs2430561 polymorphism and invasive cervical cancer (TT vs AA, OR = 1.321, 95% CI: 0.423–4.121, <i>P</i> = 0.632). The rs2430561 genotype was not associated with major clinicopathological features of invasive cervical cancer (<i>P </i><inline-formula>&gt;<math><mo>&gt;</mo></math></inline-formula> 0.05). The polymorphism had no significant effect on overall survival (<i>P</i> = 0.071) or progression free survival (<i>P</i> = 0.067) of invasive cervical carcinoma. <i>Conclusions</i>: Rs2430561 polymorphism had no effect on invasive cervical cancer susceptibility in Han females in northeastern China, and was not associated with the prognosis of invasive cervical carcinoma.</p><p><br></p>