Primary squamous cell carcinoma of the endometrium. A report of 3 cases

Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare disease of unknown etiology. Diagnosis is based on the identification of squamous cell carcinoma in the endometrium with no coexisting analogous cervical component or endometrial adenocarcinoma. There must also be no connection between the endometrial tumour and the squamous epithelium of the cervix. Although the majority of patients are classified as stage I disease, prognosis is rather dismal. We report two new cases of primary squamous cell carcinoma of the endometrium which fulfill all the above criteria and we discuss another interesting case of squamous cell carcinoma of questionable endometrial origin. Management by abdominal hysterectomy and adjuvant pelvic irradiation resulted in long-term survival of our patients.

Primary Squamous Cell Carcinoma of the Endometrium; Adenocarcinoma of the Endometrium; Squamous Cell Carcinoma of the Cervix

[1] Fluhman C. F.: "Squamous epithelium in the endometnum in benign and malignant conditions". Surg. Gynecol. Obstet., 1928, 46, 309.

[2] Glaubitz M., Kupsch E., Giinter H. H., Lelle R. J., Kuhnle H.: "Primary squamous cell carcinoma of the endometrium". Eur. J. Gynecol. Oncol., XV, 1994, 1, 37.

[3] Simon A., Kopolovic J., Beyih Y.: "Primary squamous cell careclnoma of the endometrium". Gynecol. Oncol., 1988, 34, 454.

[4] Abeler V.,K jorstad K. E.: "Endometrial squamous cell carcinoma: Report of three cases and review of the literature". Gynecol. Oncol., 1990, 36, 321.

[5] Paulsey H., Taylor C.: "International histopathological classification of tumours. Histological typing of female genital tract tumours". No 13. World Health Organization, Geneva, 1975.

[6] Orhon E., Ulgenalp I., Baset I. et al.: "Primary squamous cell carcinoma of the endometrium". Eur. J. Cancer, 1991, 27, 946.

[7] A beler V. M., Kjorstad K. E. : "Endometrial adenocarcinoma with squamous cell differentiation". Cancer, 1992, 69, 488.

[8] Razguin S.,M ayayo E.,A nton E.,A lvira R.: "Squamous cell carcinoma in situ of the endometrium as superficial extension of cervical carcinoma". Gynecol. Obstet. Invest., 1993, 35, 190.

[9] Kanbour A. I., Stock R. J.: "Squamous cell carcinoma in situ of the endometrium and fallopian tube as superficial extension of invasive cervical carcinoma". Cancer, 1978, 42, 570.

[10] Buckley C.H., Fox H.: "Biopsy Pathology of the Endometrium" London, Chapman and Hall, 1989.

[11] Baggish M.S., Woodruff J. D.: "The occurrence of squamous epithelium in the endometrium". Obstet. Gynecol. Surg., 1967, 22, 69.

[12] White A. J., Buchsbaum H. J., Macasaet M.A.: "Primary sguamous cell carcinoma of the endometrium". Obstet. Gynecol., 1973, 41, 912.

[13] Barnett H.: "Squamous cell carcinoma of the body of the uterus". J. Clin. Pathol., 1965, 18, 713.

[14] Seltzer V., Klein M., Beckman M.: "The occurrence of squamous metaplasia as a precursor of squamous cell carcinoma of the endometrium". Obstest. Gynecol., 1997, 49 (Suppl. I), 34.

[15] Taghinia M.A., Nasirai F.: "Primary squamous cell carcinoma of the endometrium. Report of a case and review of the literature" Pahlawi. Med. J., 1977, 8, 459.

[16] Piering A. Veber einen Fall von atypischer Carcinombildung im Uterus? Heilkunde, Bb 8, 1887.

[17] Goodman A., Zukemberg L. R., Rice L. W., Fuller A. F., Young R H.,S cully R. E.: "Sqau amous cell carcinoma of the endometrium: a report of eight cases and review of the literature". 1996, 61 (1), 54.

[18] Kay S.: "Squamous cell carcinoma of the endometrium". Amer. J. Clin. Pathol., 1974, 61, 264.

[19] Im D. D., Shah K. V., Rhosenshein N. B.: "Report of three new cases of squamous cell carcinoma of the endometrium with emphasis in the HPV status". Gynecol. Oncol., 1995, 56,464.

[20] Batchelor F. C., Doran A.: "Primary squamous celled epithelioma of the body of the uterus". Trans. Obstet. Soc., 1903, 45, 374.

[21] Peris L.A., Jernstrom P., Bowers P. A.: "Primary squamous cell carcinoma of the uterine corpus. Report of a case and review of the literature". Am. J. Obstet. Gynecol., 1958, 75, 1019.

[22] Bellone F.: "II carcinoma epidermoide primitive dell'endometrio. Descrizione di un caso". Arch. Obstet. Ginecol., 1968, 73, 1086.

[23] Ryder D. E.: "Verrucous carcinoma of the endometrium - a unique neoplasm with long survival". Obstet. Gynecol., 1982, 59(Suppl.), 78.

[24] Frick H. C., Munnell E.W., Richart R. M., Berger AP., Lawry M F.: "Carcinoma of the endometrium". Am. J. Obstet. Gynecol., 1973, 115, 663

[25] Chu F., LePow H., Godsick W.: "Primary squamous cell camnoma of the corpus uteri". Arch. Pathol.,1958, 65, 13.

[26] Hopkin I. D.,H arlow R.A ., Stevens P. J.: "Squamous carcmoma of the body of the uterus". Brit. J. Cancer, 1970, 24, 71.

[27] Melin J. R.,W anner C., Schulz D. M., Cassel E. E.: "Primary squamous cell carcinoma of the endometrium". Obstet. Gynecol., 1979, 53, 115.

[28] Vyas M. C. R., Joshi K. R., Mathur D. R., Sharma M. M., Mathur A.: "Primary squamous cell carcinoma of the endometrium. Report of a case and review of literature". Indian. J. Pathol Microbial., 1980, 23, 289.

[29] Yamashina M., Kobara T. Y.: "Primary squamous cell carcmoma with its spindle cell variant in the endometrium. A case report and review of literature". Cancer, 1986, 57, 340.

[30] Petterson F.,F otiou S.,E inhorn N.,S ilversward C.: "Cohort study of the long-term effects of irradiation for carcinoma of the uterine cervix". Act. Radial. (Oneal.), 1985, 24, 145.

[31] McMahon B.: "Risk factors for endometrial cancer". Gynecol. Oneal., 1974, 2, 122.

[32] Adelson M. D., Strumpf K. B.: "Squamous cell carcinoma of the endometrium presenting as peritonitis with small bowel obstruction". Gynecal. Oncol., 1992, 45, 214.

[33] Bibro M. C., Kapp D. S., LiVolsi V. A., Schwartz P. E.: "Squamous cell carcinoma of the endometrium with ultrastructural observation and review of the literature". Gynecol. Oneal., 1980, 10, 217.

[34] Mencrer J.: "Primary squamous cell carcinoma of the endometrium". Harefuah, 1975, 89, 169.

[35] Kennedy A. S., DeMars L. R., Flannagan L. M., Varia M. A.: "Primary squamous cell carcinoma of the endometrium. A first report of adjuvant chemoradiation". Gynecal. Oncol., 1995, 59, 117.

[36] Ojutiku D., Morcos S.: "Primary squamous cell carcinoma of the endometrium". J. Obstet. Gynaecal., 1995, 15 (6), 420.

[37] Curtin C. T., Mitchell V., Curtin E.: "Cytology of primary squamous carcinoma of the endometrium". Acta Cytal. (Baltimare), 1983, 27 (3), 313.

[38] Levine S., Sciorsci E. F.: "Squamous cell carcinoma of the utenne corpus and its relation to pyometra". Cancer, 1966, 19, 485.