Non diethy lstilbesterol induced vaginal adenosis-A case series and review of literature

Non diethylstilbestrol induced vaginal adenosis has a reported incidence of about 10% in adult women. Although in some, it may be an insignificant coincidental finding, it is probably under-diagnosed even in symptomatic women. Little is known about the aetiology, pathogenesis, symptomatology and management of this poorly understood condition. Our experience with the four cases of vaginal adenosis unrelated to diethylstilbestrol (DES) exposure and a review of the literature will probably shed some light on this, as it still remains an enigma in gynaecological oncology.

Vaginal adenosis; Non diethylstilbestrol; Vaginal intraepithelial neoplasia; Cervical glandular intraepithelial neoplasia

[1] Kranl C., Zeiger B., Kofler H. ·et al.: "Vulva! and vaginal adenosis". British Journal of Dermatology, 1998, 139, 128.

[2] Anderson J. R.: "Muir's textbook of pathology". Twelfth edition, 24. 3, 4.

[3] Kurman R. G., Scully R. E.: "The incidence and histiogenesis of vaginal adenosis; an autopsy study". Hum. Pathol., 1974, 5, 265.

[4] Sedlacek T. V.,R iva J.M.,M agen A. B. et al.: "Vaginal and vulvar adenosis: an unsuspected side-effect of carbon dioxide laser vaporisation". J. Reprod. Med., 35, 995.

[5] Dungar F. C., Wilkinson J.E.: "Vaginal columnar cell metaplasia; An acquired adenosis associated with topical 5-fluorouracil therapy". J. Reprod. Med.,1995, 40, 361.

[6] Bornstein J., Sova Y., Atad J. et al.: "Development of vaginal adenosis following combined 5-fluorocil and carbon dioxide laser treatments for diffuse vaginal condylomatosis". Obstet. Gynaecol., 1993, 81, 896.

[7] Singer A.,M ansell M. E., Neill S.: "Symptomatic vaginal adenosis". British J. Obstet. Gynaecol., 1994, 101, 633.

[8] Robboy S. L., Hill E. C., Sandberg E. C., Czernobilsky B.: "Vaginal adenosis in women born before diethylstilboestrol era". Hum. Pathol., 1986, 17, 488.

[9] Cook S.: "Vaginal carcinoma associated with haematocolpos: A case report and review of vaginal adenosis as a precursor lesion". Aust. J. Obstet. Gyanecol., 1995, 35 (4), 465.

[10] Scurry J., Planner R., Grant P.: "Unusual variants of vaginal adenosis: "A challenge for diagnosis and treatment". Gynecol. Oneal., 1991, 41, 172.

[11] Yagsezian H., Palazzo J.P., Finkel G. C. et al.: "Primary vaginal adenocarcinoma of the intestinal type associated with adenosis". Gynecol. Oneal., 1992, 45, 62.