Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Minor prognostic factors in squamous cell vulvar carcinoma
1Department of Radiology-Radiotherapy, Aretaieion Hospital, University of Athens, Greece
22nd Obstetrics-Gynecologic Clinic, Aretaieion Hospital, University of Athens, Greece
*Corresponding Author(s): J. R. Kouvaris E-mail:
Purpose of the study: To evaluate minor prognostic factors in a patient population with squamous cell vulvar carcinoma, with particular attention to age, smoking, obesity and parity.
Methods: A total of 50 women with invasive squamous cell vulvar carcinoma were retrospectively analyzed. Factors assessed for prognostic value included age, obesity, diabetes, hypertension, smoking and parity.
Results: The log-rank test and the univariate regression analysis revealed that all factors decreased the overall survival. In the multivariate regression analysis only age, obesity, smoking and parity were independent predictors for survival. The relative risk of death for elderly and patients, obese smokers, and patients with more than three deliveries was 1.008, 1.159, 1.411 and 2.532, respectively. Hypertension and diabetes seemed to be questionable prognostic factors.
Conclusion: Smokers, patients who had more than three children, body mass index >27, and were older than 73 years had a poorer survival rate.
Vulvar carcinoma; Prognostic factors; Smoking; Obesity; Parity
J. R. Kouvaris,V. E. Kouloulias,C. D. Loghis,E. J. Balafouta,A. C. Miliadou,L. J. Vlahos. Minor prognostic factors in squamous cell vulvar carcinoma. European Journal of Gynaecological Oncology. 2001. 22(4);305-308.
[1] Heaps J.M., Fu Y. S., Montz F. J., Hacker N. F., Berek J. S.: "Surgical-pathological variables predictive of local recurrence in squamous cell carcinoma of the vulva". Gynecol. Oncol.,1990, 38(3),309.
[2] Homesley H. D., Bundy B. N., Sedlis A., Yordan E., Berek J. S., Jahshan A.. Mortel R.: "Assessment of current International Federation of Gynecology and Obstetrics staging of vulvar carcinoma relative to prognostic factors of survival (A Gynecologic Oncology Group Study)". Am. J. Obstet. Gynecol., 1991, 164(4), 997.
[3] Piura B., Masotina A., Murdoch J., Lopes A., Morgan P., Monaghan J.: "Recurrent squamous cell carcinoma of the vulva: A study of 73 cases". Gynecol. Oncol., 1993, 48(2), 189.
[4] Kirschner C. V., Yordan E. L., De Geest K., Wilbanks G.D.: "Smoking, obesity, and survival in squamous cell carcinoma of the vulva". Gynecol. Oncol., 1995, 56(1), 79,
[5] Brinton L. A.. Nasca P. C.. Mallin K., BaptisteM. S., Wilbanks G.D., Richart R. M.: "Case control study of cancer of the vulva" Obstet. Gynecol., 1990, 75(5), 859.
[6] Busch M.. Wagener B., Duhmke E.: "Long-term results of radiotherapy alone for carcinoma of the vulva". Adv. Ther.. 1999, 16(2), 89.
[7] Shepherd J. H.: "Revised FIGO staging for gynecological cancer". Br. J. Obstet. Gynecol., 1989, 96(8), 889.
[8] Creasman W. T.: "New gynecologic cancer staging". Gynecol. Oncol.. 1995, 58(2), 157.
[9] Green T. H Jr., Ulfelder H., Meigs J. V.: "Epidermal carcrnorna: An analysis of 238 cases. I. Etiology and diagnosis". Am. J Obstet. Gynecol.. 1958, 75, 834.
[10] McKelvey J. L., Adcock L. L.: "Cancer of the vulva". J. Obstet Gynecol., 1965, 26(4), 455.
[11] Perez C. A., Grigsby P. W., Clifford Chao K. S., Garipagaoglu M: "Vulva". In: Perez C. A., Brady L. W. eds. "Principles and Praclice of Radiation Oncology". Philadelphia, Lippincott 3,d edition 1998, 1915.
[12] Abraham B., Ledolter J.: "Statistical Methods for Forecasting". New York, Wiley & Sons, 1983.
[13] Andreasson B., Nyboe J.: "Value of prognostic parameters in squamous cell carcinoma of the vulva". Gynecol. Oneal., 1985, 22(3), 341.
[14] An sink A. C., Heintz A. P.: "Epidemiology and etiology of squarnous cell carcinoma of the vulva". Eur. J. Obstet. Gynecol Reprod. Biol., 1993, 48, 11.
[15] Carter J., Carlson J., Fowler J., Hartenbach E., Adcock L., Carson L. et al.: "Invasive vu Ivar tumors in young women. A disease of the immunosuppressed?". Gynecol. Oncol., 1993, 51(3), 307.
[16] Daling.I. R., Sherman K. J.. Hislop T. G.. Maden C., Mandelson M. T., Beckmann A. M. et al.: "Cigarette smoking and the risk of anogenital cancer". Am. J. Epidemiol., 1992, 135(2), 180.
[17] O'Mara B. A., Byers T., Schoenfeld E.: "Diabetes mellitus and cancer risk: A multi、ite case-control study". J. Chronic. Dis., 1985, 38(5), 435.
[18] Frankman 0., K心ulski Z., Nilsson B., Silfversward C.: "Prognostic factors in invasive squamous cell carcinoma of the vulva". Int. J. Gynaecol. Obstet., 1991, 36(3), 219.
[19] Kosary C. L.: "FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: An analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina". Semin. Surg. Oncol., 1994, 10(1), 31.
Top