A ten-year remission maintained by 6272 mg (3920 mg/m2) cumulative dose of cisplatin-based chemotherapy for recurrent epithelial ovarian cancer

Since cisplatin is a heavy metal, renal and neurotoxicity is considered to be dose limiting in solid tumors. The current case is unusual in that remission has been maintained in a patient with recurrent epithelial ovarian cancer by cisplatin-based chemotherapy without evidence of renal or neurotoxicity, while receiving a total dose of 6,270 mg (3,920 mg/m2) of cisplatin over 11 1/2 years.

Chemotherapy; Cisplatin; Ovarian cancer

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