Epidermoid cyst and primary trabecular carcinoid of the ovary: case report

In the literature and in our experience epidermoid cysts and carcinoids of the ovary are rare benign pathologies which occur more frequently in younger women. They probably are a one-sided development of a teratoma, which arise from germ cells after the first meiotic division due to either a meiosis I or a meiosis II non dysjunction. Diagnosis is possible only with histological examination and immunohistochemistry which allow us to differentiate carcinoids from sex-cord tumors and ependymomas. Prognosis is very good because the rate of malignant transformation is 1.4%-2% and the rate of complications is 14%. Thus conservative surgical therapy associated with long-term follow-up is the treatment of choice.

Ovarian epidermoid cyst; Ovarian trabecular carcinoid

[1] Nogales F. F., Silverberg S. G.: "Epidermoid cysts of the ovary : A report of five cases with histogenetic considerations and ultrastructural findings." Am. J. Ohstet. Gynecol., 1976, 124, 5, 523.

[2] Dahl N., Gustavson K-H et al.: "Benign ovarian teratomas". Cancer Genet. Cytogenet., 1990, 46, 115.

[3] Ayhan A., Bukulrnez 0. et al.: "Mature cystic teratomas of the ovary: case series from one institution over 34 years". Eur. J. Ohstet. Gynecol. Reprod. Biol., 2000, 88, 153.

[4] Deka R.,C hakravarti A. et al.: " Genetics and biology of human ovarian teratornas. II. Molecular analysis of origin of nondisjunction and gene-centromere mapping of chromosome I markers." Am. J. Hum. Genet., 1990, 47, 644.

[5] Noumoff J. S., Livolsi V. A. et al.: "Chromosome analysis and comparison of the benign cystic and malignant squamous component of an ovarian teratoma." Cancer Genet. Cytogenet., 2001, 125, 59.

[6] Surti U., Hoffner L. et al.: "Genetics and biology of human ovarian teratornas. I. Cytogenetic analysis and mechanism of origin." Am. J. Hum. Genet., 1990, 47, 635.

[7] Hilton P., Tweddell A. et al.: "Primary insular argentaffin carci- noma of the ovary. Case report and literature review." Brit. J. Ohstet. Gynaecol., 1988, 95, 1324.

[8] Davis K. P., Hartmann L. K. et al.: " Primary ovarian carcinoid tumors". Gynecol. Oncol., 1996, 61, 259.

[9] Talerman A., Evans M. I.: "Primary trabecular carcinoid tumor of the ovary". Cancer, 1982, 50, 1403.

[10] Talerman A., Okazaki T.: " Ultrastructural features of primary trabeculat carcinoid tumor of the ovary". Int. J. Gynecol. Pathol., 1985, 160, 153.

[11] Soga J., Osaka M. et al.: "Carcinoids of the ovary: an analysis of 329 reported cases". J. Exp. Clin. Cancer Res., 2000, 19, 3, 271.

[12] Robboy S. J., Norris S. J.: "Insular carcionid primary in the ovary: a_ clinicopathologic analysis of 48 cases." Cancer, 1975, 36, 404.

[13] Ozercan I. H., Coblanoglu B. et al.: "Epidermoid cyst of the ovary: case report." Pathologica, 2000, 92, 284.