Low and high grade mucoepidermoid carcinomas of the breast

Mucoepidermoid carcinoma is a very rare primary tumour of the breast. Until now only 17 cases have been described in the literature. Generally these malignancies have a good prognosis, especially if well differentiated. We report a case of low-grade which recurred as high-grade after 32 months. She also developed a poorly differentiated adenocarcinoma in the other breast 12 years after her initial treatment. At present the patient is well without any sign of disease for 156 months. A literature review of this rare entity is presented.

Mucoepidermoid carcinoma; Breast cancer; Pathology; Prognosis

[1] Brandwein M. S., Ivanov K., Wallace D. I., Hille J. J., Wang B., Fahmy A. et al.: "Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading". Am. J. Surg. Pathol., 2001, 25, 835.

[2] Fisher E. R., Palekar A. S., Gregorio R. M., Paulson J. D.: "Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumours". Am. J. Surg. Pathol., 1983, 7, 15.

[3] Pachevsky A. S., Frauenhoffer C. M., Krall R. A., Cooper H. S.: "Low-grade mucoepidermoid carcinoma of the breast". Arch. Pathol. Lab. Med., 1979, 103, 196.

[4] Kovi J., Duong H. D., Leffall L. S.: "High-grade mucoepidermoid carcinoma of the breast". Arch. Pathol. Lab. Med., 1981, 105, 612.

[5] Retanarapee S., Prinyar-Nussom N., Chantarakul N., Pacharee P.: "High-grade mucoepidermoid carcinoma of the breast. A case report". J. Med. Assoc. Thai., 1983, 66, 642.

[6] Leong A. S., Williams J. A.: "Mucoepidermoid carcinoma of them breast: high grade variant". Pathology, 1985, 17, 516.

[7] Hanna W., Kahn, H.J.: "Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast". Hum. Pathol., 1985, 16, 941.

[8] Hastrup N., Sehested M.: "High-grade mucoepidermoid carcinoma of the breast". Histopathology, 1984, 9, 887.

[9] Luchtrath H., Moll R.: "Mucoepidermoid mamary carcinoma. Immunohistochemical and biochemical analyses of intermediate filaments". Virch. Arch. A. Pathol. Anat. Histopathol., 1989, 416, 105.

[10] Pettinato G., Insabato L., De Chiara A., Manco A., Petrella G.: "High-grade mucoepidermoid carcinoma of the breast. Fine needle aspiration cytology and clincopathologic study of a case". Acta. Cytol., 1989, 33, 195.

[11] Berry M. G., Caldwell C., Carpenter R.: "Mucoepidermoid carcinoma of the breast: a case report and review of the literature". Eur. J. Surg. Oneal., 1998, 24, 78.

[12] Markopoulos C., Gogas H., Livaditous A., Floros D.: "Mucoepidermoid carcinoma of the breast". Eur. J. Gynaecol. Oneal., 1998, 19, 291.

[13] Tjalma W., Van Schill P., Verbist A. M., Buytaert P., van Dam P.: "Chest wall resection for local recurrence of breast cancer". Eur. J. Obstet. Gynecol. Reprod. Biol., 1999, 84, 89.