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Original Research

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Does adjuvant chemotherapy improve the prognosis of cervical carcinoma with lymph-node metastasis? A long-term follow-up

  • B. Mossa1,*,
  • M. L. Framarino1
  • C. Napolitano2
  • R. Marziani2
  • F. lmperato1
  • L. Marzetti1

1Department of Gynecological Sciences, Perinatology and Child Health, I School of Medicine, Italy

2Division of Obstetrics and Gynecology, Sant'Andrea Hospital, II School of Medicine, University of Rome "La Sapienza", Italy

DOI: 10.12892/ejgo20030133 Vol.24,Issue 1,January 2003 pp.33-40

Published: 10 January 2003

*Corresponding Author(s): B. Mossa E-mail:

Abstract

Objective: to verify the efficacy of adjuvant therapy in the prevention of neoplastic recurrence in patients at high risk for lymph-node involvement on surgical examination.

Methods: 72 patients, suffering from squamous cell cervical carcinoma Stage IB-IIB (FIGO) who underwent radical hysterectomy with lymph-node involvement confirmed at the final histological examination, were enrolled. All the patients were treated with adjuvant chemotherapy (AC), which included cisplatin, bleomycin and vinblastine, and were followed for a minimum period of six years. The results were compared with those obtained with a historical group of 78 patients, with comparable age, stage and lymph-node involvement, on whom only radical surgery (RS) was performed.

Results: the average total survival rate of the two groups (RS + AC vs RS) at five years was 63.9% and 55.1%, respectively (chi2 = 1.191; p = NS). The disease-free interval was 55.6% vs 46.2% (chi2 = 1.324; p = NS). The best results were obtained in cases where the common iliac lymph-nodes were affected, with the highest survival rate of 16.9% in the RS+AC group, out of a total of 25 cases.

Conclusions: adoption of adjuvant chemotherapy in patients at high risk for lymph-node positivity did not produce statistically significant results in terms of overall and disease-free survival; however, a small number of these patients, approximately 9%, could receive benefit from the treatment.

Keywords

Cervical cancer; Adjuvant chemotherapy; Lymph-node metastasis

Cite and Share

B. Mossa,M. L. Framarino,C. Napolitano,R. Marziani,F. lmperato,L. Marzetti. Does adjuvant chemotherapy improve the prognosis of cervical carcinoma with lymph-node metastasis? A long-term follow-up. European Journal of Gynaecological Oncology. 2003. 24(1);33-40.

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