Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Management of pregnancy-associated acute leukemia
1Department of Internal Medicine, Tri-Service General Hospital, School of Public Health, National Defense Medical Center, Republic of China
2Department of Gynecology and Obstetrics, Tri-Service General Hospital, Republic of China
3Division of Hematology and Oncology, Tri-Service General Hospital, Taiwan, Republic of China
*Corresponding Author(s): WY Kao E-mail:
Since leukocystosis and anemia are common findings in pregnancy, pathological alterations in hematopoesis, such as leukemias, can sometimes proceed undetected. Chemotherapy during pregnancy carries the risk of teratogenic effects on the fetus, and there is little data to guide chemotherapeutic regimens for leukemia during pregnancy. The following paper describes our experience in treating two women with acute leukemia during pregnancy and the immediate postpartum period, and reviews the relevant literature.
Acute leukemia; Chemotherapy; Pregnancy
WL Su,JY Liu,WY Kao. Management of pregnancy-associated acute leukemia. European Journal of Gynaecological Oncology. 2003. 24(3-4);251-254.
[1] McLain C.R Jr.: "Leukemia in pregnancy". Clinical Obstetrics & Gynecology, 1974, 17 (4), 185.
[2] Peleg D., Ben-Ami M.: "Lymphoma and leukemia complicating pregnancy". Obstet. Gynecol. Clinics No. Am., 1998, 25 (2), 365.
[3] Lynch S.R.: "The potential impact of iron Lympplementation during adolescence on iron status in pregnancy". J. Nutrit., 2000, I 30 (2S suppl.): 448S.
[4] Schwartz W.J. 3nd Thurnau G.R.: "Iron deficiency anemia m pregnancy". Clin. Obstet. Gynecol., 1995, 38 (3), 443.
[5] Branch D.W.: "Physiologic adaptations of pregnancy". Am. J Reprod. Immunol., 1992, 28 (3-4), 120.
[6] Zuazu J., Julia A., Sierra J. et al.: "Pregnancy outcome in hematologic malignancies". Cancer, 1991, 67 (3), 703.
[7] Camera A., Campanile M., Catalano D., Mattace Raso A., Rotoh B.: "Relapse of acute lymphoblastic leukemia during pregnancy" Eur. J. Gynaecol. Oncol., 1996; 17 (4), 303. Division of Statistics, Department of Health. Health and vital statistics, Taiwan area, R.O.C., 1999, 75.
[8] Sadural E. Smith LG. Jr.: "Hematologic malignancies during pregnancy". Clin. Ob.stet. Gynecol., 1995, 38 (3), 535
[9] Caligiuri M.A., Mayer R.J.: "Pregnancy and leukemia". Sem. Oncol., 1989, 16 (5), 388.
[10] Maloisel F., Dreyfus M., Neuhart D., Ritter J., Oberling F.: "Management of hematologic malignancies during pregnancy". J. Gynecologie,Obstetrique et Biologie de la Reproduction, 1996, 25 (6), 602.
[11] Aviles A., Niz J.: "Long-term follow-up of children born to mothers with acute leukemia during pregnancy". Med. Pediat Oncol., 1988, 16 (1), 3.
[12] Kawamura S., Tsushima K., Sakata Y.: "Pregnancy outcome in long-term survivors with adult acute leukemia, malignant lymphoma and breast cancer". lap. J. Cancer Chemothet:, 1996, 23 (7), 821.
[13] Lishner M., Koren G.: "Cancer chemotherapy dunng pregnancy Consortium of cancer in pregnancy evidence". Can. Fam. Phys.. 2001,47,41.
[14] Brell J., Kalaycio M.: "Leukemia in pregnancy". Sem. Oncol.. 2000, 27 (6), 667.
[15] Doll D.C.,R ingenberg Q.S.,Y arbro J.W.: "Management of cancer during pregnancy". Archives Inter. Med., 1988, 148 (9), 2058.
[16] Barber H.R.: "Fetal and neonatal effects of cytotoxic agents". Obstet. Gynecol., 1981, 58 (suppl.), 41S.
[17] Blatt J., MulvihiII J.J.,Z iegler J.L., Young R.C., Poplack D.G.: "Pregnancy outcome following cancer chemotherapy". Am. J. Med., 1980, 69 (6), 828.
[18] Boike G.M., Deppe G., Young J.D., Malone J.M. Jr., Malviya V.K., Sokol R.J.: "Chemotherapy in a pregnant rat model. 2.5-tluorouracil: nonlinear kinetics and placental transfer". Gynecol. Oncol., 1989, 34 (2), 191.
[19] Shamkhani H., Anderson L.M., Henderson C.E., Moskal T.J., Runowicz C.D., Dove L.F. et al.: "DNA adducts in human and patas monkey maternal and fetal tissues induced by platinum drug chemotherapy". Reprod. Toxicol., 1994, 8 (3), 207.
[20] Hansen W.F., Fretz P., Hunter S.K., Yankowitz J.: "Leukemia in pregnancy and fetal response to multiagent chemotherapy" Obstet. Gynecol., 2001, 97 (5Pt 2), 809.
[21] Garcia L., Valcarcel M., Santiago-Borrero P.J.: "Chemotherapy during pregnancy and its effects on the fetus-neonatal myelosuppression: two case reports". J. Perinat., 1999, 19 (3), 230
[22] Buekers T.E., Lallas T.A.: "Chemotherapy in pregnancy". Obstet Gynecol. Clinics No. Am.. 1998, 25 (2), 323.
[23] Murray NA, Acolet D, Deane M, P rice J, Roberts IA. Fetal marrow suppression after maternal chemotherapy for leukemia Archives Dis. Childhood Fetal Neonatal Ed. 1994, 71 (3), F209.
[24] Feliu J., Juarez S., Ordonez A., Garcia-Paredes M.L., GonzalezBaron M., Montero J.M.: "Acute leukemia and pregnancy". Cancer, 1988, 61 (3), 580.
[25] Sweet D.L. Jr., Kinzie J.: "Consequences of radiotherapy and antineoplastic therapy for the fetus". J. Reprod. Med., 1976, 17 (4), 241.
[26] Mccredie K.B., Gehan E.A., Freireich E.J., Hewlett J.S., Coltman C.A. Jr., Hussein K.K. et al.: "Management of adult acute leukemia. A Southwest Oncology Group study". Cancer, 1983, 52 (6), 958.
[27] Ho C.L., Chen Y.C., Kao W.Y., Chao TY.: "Acute lymphoblastic leukemia in young adults: two chemotherapeutic protocols for the treatment of 46 patients". Chung Hua i Hsueh Tsa Chih - Chin. Med. J., 2000, 63 (1), 45.
[28] Styczynski J.,Pieters R., Huismans D.R., Schuurhuis G.J., Wysocki M., Veerman A.J.: "In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia". Br. J. Haematol.. 2000, 110 (4), 813.
Top