Vaginal bleeding as a first symptom of malignant lymphoma: Case reports, diagnosis and successful treatment

Uncommon pathologic changes of the uterine cervix are rare but not impossible. Described cases of cervical lymphoma indicate the necessity of great attention and careful diagnosis. A watchful examination, imaging procedures and detailed histopathologic findings are of crucial importance in treatment planning. Each of our three patients underwent different types of treatment. A proper choice of therapeutical methods is based on individual disease and patient performance status features. In our patients, chemotherapy, radiotherapy (brachy- and teletherapy) were considered and applied as the sole method or in combination.

Malignant lymphoma; Vaginal malignancy; Chemotherapy; Vaginal irradiation

[1] Barini A., Basile F., Bordino S., Cardesi E., Cera G.: "Pnrnary non-Hodgkin's lymphoma of the vagina: a rare case". Min Ginecol., 1993, 45 (12), 633.

[2] Clow W. M., Joannides T., Salem A. K. N., Melville-Jones G. R., Martin J.: "An unusual cause of postrnenopausal bleeding and incontinence of urine: primary lymphoma of the vagina". Br. J Obstet. Gynecol., 1995, 102, 164.

[3] Hoffk.es H. G., Schumann A., Uppenkamp M.. Tscndorf C., Schindler A. E., Parawaresch, Brittinger G.: "Primary nonHodgkin's lymphoma of the vagina. Case report and review of the literature". Ann. Haematol., 1995, 70 (5), 273.

[4] Prevot S., Hugo! D., Audouin J.: "Primary non-Hodgkin's mahgnant lymphoma of the vagina: Report of 3 cases with review the literature". Pathol. Res. Pract., 1992, 188, 78.

[5] Torrubia S, Sabate JM, Palmer J, Martinez-Noguera A.: "Plasmacytoma of the vagina: Findings on CT and MR imaging". Am. J Roentg., 2002, 178, 245.

[6] Chalubinski K., Breitenecker G., Tatra G.: "Malignant lymphomas of the vulva and vagina". Geburtsh Frauenheilk., 1992, 52 (10), 630.

[7] Perren T., Farrant., McCarthy K., Harper P., Wiltshaw E.: "Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature". Gynecol. Oncol., 1992, 44. 87.

[8] Levitan Z., Gordon A., Kaplan A. et al.:''Primary malignant melanoma of the vagina: Report of four cases and review of literature". Gynecol. Oncol., 1989, 33, 85.

[9] Das灿lakis G. J., Karabinas C. D., Papantaniou N. E., Paspyrou I., A., Antsaklis A. J., Michalas S.: "Vaginal fibroma. Case report" Eur. J. Gynecol. Oncol., 2002, 23, 6, 575.

[10] Wiebren A.A., Tjalma W. A. A., Van de Vclde A. L. R., Schroyens W.A.M.: "Primary non-Hodgkin's lymphoma in Bartholin's gland". Gynaecol. Oncol., 2002, 87, 3, 308.

[11] Hoskins W. J., Perez C. A., Young C. R.: "Principles and Practice of Gynecologic Oncology". New York, Lippincott-Raven, 1997, 759.