Cervical cancer and low-risk HPV; a case report

A case of cervical cancer in a 32-year-old woman with a genotype 6 HPV genital infection that developed from a cervical low-grade SIL after a LLETZ procedure two years before is presented. This case obliges us to reconsider both the benign nature of low-grade lesions and the potentially good prognosis of low-risk HPV infection.

Cervical cancer; Low-grade; Low-risk; HPV infection; Genotype 6

[1] Bosh F.X., Manos M.M., Muiioz N., Sherman M., Cansen A.M., Peto J. et al.: "Prevalence of human papillomavirus in cervical cancer: a worldwide perspective". J. Natl. Cancer Inst., 1995, 87, 796.

[2] Chaouki N., Bosch F.X., Muiioz N., Meijer C.J.L.M., El Gueddari B., El Ghazi A. et a/.:''The viral origin of cervical cancer in Rabat, Morocco". Int. J. Cancer, 1998, 75, 546.

[3] Chichareon S., Herrero R., Muiioz N., Bosch F.X., Jacobs M.V., Deacol) J. et al.: "Risk factors for cervical cancer in Thailand: a case-control study". J. Natl. Cancer Inst., 1998, 90, 50.

[4] Ngelangel C., Muiioz N., Bosch F.X., Limson G.M., F estin M.R., Deacon J. et al.: "Causes of cervical cancer in the Philippines: a case control study". J. Natl. Cancer Inst., 1998, 90, 43.

[5] Stoler M.H.: "A brief synopsis of the role of human papillomaviruses in cervical carcinogenesis". Am. J. Obstet. Gynecol., 1996, 175, 1091.

[6] Anderson S., Rylander E., Larsson B., Strand A., Silfversvard C., Wilander E.: "The role of human papillomavirus in cervical adenocarcinoma carcinogenesis", Eur. J. Cancer, 2001, 37, 246.

[7] Chaouki N., Bosch F.X., Muiioz N., Meijer C.J., El Gueddari B., El Ghazi A.: "The viral origin of cervical cancer in Rabat, Morocco". Int. 1 Cancer, 1998, 75, 546.

[8] Brinton L.: "Epidemiology of cervical cancer-overview". In: Muiioz N., Bosch F.X., Shah K., Meheus A. (eds.). The Epidemic ology of Human Papillomavirus and Cervical Cancer. Lyon IARC, 1992, 2.

[9] Slattery M.L., Robison L.M., Schuman K.L. et al.: "Cigarette smoking and exposure to passive smoke are risk factors for cervical cancer". JAMA, 1989, 261, 1593.

[10] Rakowicz-Szulczynska E.M., McIntosh D.G., Perry M., Sith M.I.: "PDGF AA as mediator in nicotine-dependent carcinogenesis". Carcinogenesis, 1996, 17, 1813.

[11] Benedet J., Odicino F., Maisonneuve P., Severi G., Creasman W., Shepherd J. et al.: "Carcinoma of the cervix uteri. Annual report on the results of treatment in gynecological cancer". J. Epidemiol. Biostat., 1998, 3, 63.

[12] Pellerson F.: "Secondary prevention screening for carcinoma of the cervix". In: Kavanagh J.J., Singletary S.E., Einhorn N., De Pretrillo AD. (eds.). Cancer in Women. Massachusetts, Blackwell Science, 240.

[13] Gonzalez-Merlo J., Gonzalez-Bosquet E., Biete A., Casanova L.I., Mestres J.: "Cancer de cervix. Ginecologfa Oncol6gica, 2'edici6n, Masson, Barcelona 2000, 141.

[14] Wilcynsky S.P., Oft M., Cook N., Liao S.Y., Iftner T.: "Human papillomavirus type 6 in squamous cell carcinoma of the bladder and cervix". Hum. Pathol., 1993, 24, 96.

[15] Villa L.L., Costa R.L., Petta C.A., Andrade C.A., Ault K.A., Giulano A.R. et al.: "Prophylactic quadrivalent human papillomavirus (type 6, 11, 16 and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial". Lancet Oneal., 2005, 6, 271.

[16] Clifford G.M., Smith J.S., Plummer M., Muiioz N., F ranceschi S.: "Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis". Br. J. Cancer, 2003, 88, 63.

[17] Oft M., Bohm S., Wilcynsky S.P., Iftner T.: "Expresi6n of different viral mRNAs of human papilloma virus 6 in a squamous-cell carcinoma of the bladder and the cervix". Int. J. Cancer, 1993, 53,924.