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Original Research

Open Access

Immunoreactivities of human nonmetastatic clone 23 and p5 3 products are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients

  • Y.T. Tee11,2
  • P.H. Wang2
  • J.L. Ko3
  • G.D. Chen2
  • H. Chang4
  • L.Y. LIN1,*,

1Institute of Medicine, Chung Shan Medical University, Taiwan

2Department c!f Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taiwan

3Institute of Medical and Molecular Toxicology, 4Department of Pathology, Chung Shan Medical University Hospital, Taiwan

DOI: 10.12892/ejgo20070118 Vol.28,Issue 1,January 2007 pp.18-22

Published: 10 January 2007

*Corresponding Author(s): L.Y. LIN E-mail:

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Abstract

Objective: To assess the relation between expressions of human nonmetastatic clone 23 (nm23-H1) and p53 in cervical cancer, their relationships with lymph node metastasis, and further to examine their predictive of lymph node metastases.

Materials and methods: nm23-H1 and p53 expression profiles were visualized by immunohistochemistry in early-stage cervical cancer specimens.

Results: Immunoreactivities of nm23-H1 and p53 were disassociated. The independent variables related with lymph node metastases were grade of cancer cell differentiation (p < 0.029) and stromal invasion (p < 0.039). Sensitivity, specificity, positive and negative predictive values, and accuracy for lymph node metastasis were calculated to be 91.7%, 13.5%, 25.6%, 83.3%, and 32.7% for nm23-H1 and 66.7%, 51.4%, 30.8%, 82.6%, and 55.1% for p53.

Conclusion: Nm23-H1 and p53 are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients. However, stromal invasion and cell differentiation can predict lymph node metastasis.


Keywords

Early-stage cervical cancer; Human nonmeta tatic clone 23; p53; Lymph node metastasis; Grade of cell differentiation; Stromal invasion

Cite and Share

Y.T. Tee1,P.H. Wang,J.L. Ko,G.D. Chen,H. Chang,L.Y. LIN. Immunoreactivities of human nonmetastatic clone 23 and p5 3 products are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients. European Journal of Gynaecological Oncology. 2007. 28(1);18-22.

URL:

https://www.ejgo.net/articles/10.12892/ejgo20070118

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