Late recurrence of ovarian granulosa cell tumor at the retroperitoneal and renal hilum level in a single-kidney patient - case report

Background: Ovarian granulosa cell tumors are rare tumors characterized by a long natural history and a tendency to late recurrence. Surgical resection, radiotherapy, chemotherapy and hormone therapy are possible options to treat recurrent disease. The choice will depend on the patient's condition and the site of recurrence. Case: We describe the case of a 72-year-old patient with a single left kidney who presented retroperitoneal recurrence of ovarian granulosa cell tumor at the left renal hilum ten years after primary treatment. Conclusion: This case illustrates an example of very late recurrence and emphasizes the importance of extended follow-up for these patients.

Granulosa cell tumor; Ovary; Recurrence; Retroperitoneal nodal metastasis

[1] Baak J.P., Wisse-Brekelmans E.C., Langley FA., Talerman A., Delemarre J.F.: "Morphometric data to FIGO stage and histological type and grade for prognosis of ovarian tumours". J. Clin. Pathol., 1986, 39, 1340.

[2] Segal R., DePetrilo A.O., Thomas G.: "Clinical review of adult granulosa cell tumors of the ovary". Gynecol. Oncol., 1995, 56, 338.

[3] Crew K.D., Cohen M.H., Smith D.H., Tiersten A.D., Feirt N.M., Hershman D.L.: "Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature". Gynecol. Oncol., 2005, 96, 235.

[4] Hines J.F., Khalifa M.A., Moore J.L., Fine K.P., Lage J.M., Barnes W.A.: "Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature". Gynecol. Oneal., 1996, 60, 484.

[5] Givalos N., Liakakos T., Machairas A., Gakiopoulou H., Karatzas G.: "Sequential recurrences of ovarian granulosa cell tumour 10 and 11 years after initial diagnosis as haemoperitoneum and subhepatic mass: a case report and review of the literature". Eur. J. Gynaecol. Oneal., 2005, 26, 572.

[6] Abu-Rustum N.R., Restivo A., Ivy J., Soslow R., Sabbatini P., Sonoda Y., Barakat R.R., Chi D.S.: "Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary" Gynecol. Oneal., 2006, 103, 31.

[7] Miller B.E., Barron B.A., Wan J.Y., Delmore J.E., Silva E.G., Gershenson D.M.: "Prognostic factors in adult granulosa cell tumor of the ovary". Cancer, 1997, 79, 1951.

[8] Wolf J.K., Mullen J.，Eifen P.J., Burke T.W., Levenback C., Gershenson D.M.: "Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary". Gynecol. Oneal., 1999, 73, 35.

[9] Samant R., Fung M.F., Le T., Hopkins L., Senterman M.: "Palliative radiotherapy for recurrent granulosa cell tumor of the ovary a report of 3 cases with radiological evidence of response" Gynecol. Oneal., 2006, 102, 406.

[10] Uygun K., Aydiner A., Saip P., Kocak Z., Basaran M., Dincer M., Topuz E.: "Clinical parameters and treatment results in recurrent granulosa cell tumor of the ovary". Gynecol. Oncol., 2003, 88, 400.

[11] Williams S.D., Blessing J.A., Moore D.H., Homesley H.D., Adcock L.: "Cisplatin, vinblastine and bleomycin in advanced and recurrent ovarian germ-cell tumors. A trial of the Gynecologic Oncology Group". Ann. Intern. Med., 1989, 111, 22.

[12] Tresukosol D., Kudelka A.P., Edwards C.L., Charnsangavej C., Narboni N., Kavanagh J.J.: "Recurrent ovarian granulosa cell tumor: a case report of a dramatic response to Taxol". Int. J. Gynecol. Cancer, 1995, 5, 156.

[13] Hardy R.D., Bell J.G., Nicely C.J., Reid G.C.: "Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature". Gynecol. Oncol., 2005, 96, 865.