Uterine leiomyosarcoma metastasis to the breast

Background: Uterine leiomyosarcoma is a rare female neoplasm with a high recurrent and metastatic rate. However, only a few cases have been reported on metastasis to the breast. The purpose of this work is to stress the role of follow-up and to increase physicians' awareness of such lesion. Case: A 62-year-old female suffered from a breast nodule and multiple metastases six years after resection for uterine leiomyosarcoma. Pathology revealed a rare condition of uterine leiomyosarcoma with breast metastasis. Conclusion: The case highlights the important role of long-term follow-up in uterine leiomyosarcoma and implies the necessity of tissue proof in patients with the disease.

Uterine leiomyosarcoma; Breast tumor; Metastasis

[1] Georgiannos S.N., Chin J., Goode A.W., Sheaff M.: “Secondary neoplasmas of the breast: A survey of the 20th century”. Cancer, 2001, 92, 2259.

[2] Shukla R., Pooja B., Radhika S., Nijhawan R., Rajwanshi A.: “Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast”. Diagn. Cytopathol., 2005, 32, 193.

[3] Echt G., Jepson J., Steel J., Langholz B., Luxton G., Hernandez W., Astrahan M., Petrovich Z.: “Treatment of uterine sarcomas”. Cancer, 1990, 66, 35.

[4] Mayerhofer K., Obermair A., Windbichler G., Petru E., Kaider A., Hefler L. et al.: “Leiomyosarcoma of the uterus: A clinicopathologic multicenter study of 71 cases”. Gynecol Oncol., 1999, 74, 196.

[5] Rose P.G., Piver M.S., Tsukada Y., Lau T.: “Patterns of metastasis in uterine sarcoma. A autopsy study”. Cancer, 1989, 63, 935.

[6] Lin C.H., Yeh C.N., Chen M.F.: “Breast meatstasis from uterine leiomyosarcoma: a case report”. Arch. Gynecol. Obstet., 2003, 267, 233.

[7] Madigan M.N., Dempsey P.J., Krishnamurthy S.: “Ultrasoundguided fine needle aspiration cytodiagnosis of leiomyosarcoma metastatic of the breast: a case report”. Acta Cytologica, 2003, 47, 783.