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Original Research

Open Access

Sentinel lymph nodes in endometrial cancer: is hysteroscopic injection valid?

  • D. Clement1,4
  • A.S. Bats1,4
  • N. Ghazzar-Pierquet2
  • M.A. Le Frere Belda3,4
  • F. Larousserie1,4
  • C. Nos1,4
  • F. LÉCURU1,4,*,

1Service de Chirurgie Gynécologique et Cancérologique, Hôpital Européen Georges Pompidou, France

2Département de Médecine Nucléaire, Hôpital Européen Georges Pompidou, France

3Service d’Anatomie Pathologique, Hôpital Européen Georges Pompidou, France

4Université Paris-Descartes, Faculté de Médecine, Paris, France

DOI: 10.12892/ejgo200803239 Vol.29,Issue 3,May 2008 pp.239-241

Published: 10 May 2008

*Corresponding Author(s): F. LÉCURU E-mail: fabrice.lecuru@egp.aphp.fr

Abstract

We aimed to describe hysteroscopic peritumoral tracer injection for detecting sentinel lymph nodes (SLNs) in patients with endometrial cancer and to evaluate tolerance of the procedure, detection rate and location of SLNs. Five patients with early endometrial cancer underwent hysteroscopic radiotracer injection followed by lymphoscintigraphy, then by surgery with hysteroscopic peritumoral blue dye injection, and radioactivity measurement using an endoscopic handheld gamma probe. SLNs and other nodes were sent separately to the pathology laboratory. SLNs were evaluated by hematoxylin-eosin-saffron staining and, when negative, by immunohistochemistry. Tolerance of the injection by the patients was poor (mean Visual analog scale score, 8/10). SLNs were detected in only two patients (external iliac and common iliac+paraaortic, respectively). Detection rates were 1/5 by radiotracer, 1/5 by dye, and 2/5 by the combined method. One SLN was involved in a patient whose other nodes were negative. In three patients no SLNs were found by radiotracer or blue dye. Of the 83 non sentinel nodes removed from these patients, none was involved. Hysteroscopic peritumoral injection may be more difficult than cervical injection and, in our experience, carries a lower SLN detection rate.

Keywords

Endometrial cancer; Sentinel lymph node; Hysteroscopy; Paraaortic chain

Cite and Share

D. Clement,A.S. Bats,N. Ghazzar-Pierquet,M.A. Le Frere Belda,F. Larousserie,C. Nos,F. LÉCURU. Sentinel lymph nodes in endometrial cancer: is hysteroscopic injection valid?. European Journal of Gynaecological Oncology. 2008. 29(3);239-241.

References

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