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Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature

  • K.R. Brown1
  • M.M. Leitao2,*,

1Maternal Fetal Medicine, UMDNJ, Newark, NJ

2Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (USA)

Academic Editor: M.M. Leitao

DOI: 10.12892/ejgo201001107 Vol.31,Issue 1,January 2010 pp.107-108

Published: 10 January 2010

Fund:



*Corresponding Author(s): M.M. Leitao E-mail: gynbreast@mskcc.org

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Abstract

We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix. This occurred after the first cycle of cisplatin and then again after the second cycle. Carboplatin was substituted for cisplatin, and there were no further episodes of SIADH.

Keywords

Cisplatin; SIADH; Cervix; Syndrome of inappropriate antidiuretic hormone; Neuroendocrine tumor.

Cite and Share

K.R. Brown,M.M. Leitao. Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature. European Journal of Gynaecological Oncology. 2010. 31(1);107-108.

URL:

https://www.ejgo.net/articles/10.12892/ejgo201001107

References

[1] Levin L., Sealy R., Barron J.: “Syndrome of inappropriate antidiuretic hormone secretion following dis-dichlorodiammineplatinum II in a patient with malignant thymoma”. Cancer, 1982, 50, 2279.

[2] Porter A.T.: “Syndrome of inappropriate antidiuretic hormone secretion during cis-dichlorodiammineplatinum therapy in a patient with an ovarian carcinoma”. Gynecol. Oncol., 1985, 21, 103.

[3] Otsuka F., Hayashi Y., Ogura T., Hayakawa N., Ikeda S., Makino H., Ota Z.: “Syndrome of inappropriate secretion of antidiuretic hormone following intra-thoracic cisplatin”. Intern. Med., 1996, 35, 290.

[4] Cao L., Joshi P., Sumoza D.: “Renal salt-wasting syndrome in a patient with cisplatin-induced hyponatremia: case report”. Am. J. Clin. Oncol., 2002, 25, 344.

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