Aggressive deep angiomyxoma - a case report and review of the literature

Background: Aggressive deep angiomyxoma (AA) is locally infiltrative, non-metastasizing neoplasm that typically occurs in the pelvis and perineum in women of the reproductive age. Local recurrence is high despite apparently complete surgical resection. Case: The authors describe a case of AA in the pelvis in a 27-year-old woman. She underwent one invasive diagnostic procedure and three surgical interventions during four months, due to diagnostic problems and very early recurrence of the disease. Follow-up one year later revealed no recurrence. Conclusion: The present case confirms that AA are locally aggressive and notorious for local recurrence. Such an early recurrence of AA has not been described in available literature.

Aggressive angiomyxoma; Surgery; Recurrence

[1] Steeper T.A., Rosai J.: “Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm”. Am. J. Surg. Pathol., 1983, 7, 463.

[2] Haldar K., Martinek I.E., Kehoe S.: “Aggressive angiomyxoma: a case series and literature review”. Eur. J. Surg. Oncol., 2010, 36, 335.

[3] Salman M.C., Kuzey G.M., Dogan N.U., Yuce K.: “Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis”. Arch. Gynecol. Obstet., 2009, 280, 485.

[4] Dierickx I., Deraedt K., Poppe W., Verguts J.: “Aggressive angiomyxoma of the vulva: a case report and review of literature”. Arch. Gynecol. Obstet., 2008, 277, 483.

[5] Ohene-Yeboah M., Bewtra C.: “Aggressive angiomyxoma in African women: a report of two cases”. West. Afr. J. Med., 2009, 28, 333.

[6] Sasko A., Ferancˇíková Z., Korbel’ M., Danihel L’., Ondruš B., Holománˇ M. et al.: “Aggressive angiomyxoma in the pelvic region and adjacent tissues and organs in a woman. Case report and literature review”. Cˇes Gynek., 1996, 61, 240.

[7] Siassi R.M., Papadopoulos T., Matzel K.E.: “Metastasizing aggressive angiomyxoma”. N. Engl. J. Med., 1999, 341, 1772.

[8] Blandamura S., Cruz J., Vergara L.F., Puerto I.M., Ninfo V.: “Aggressive angiomyxoma: a second case of metastasis with patient’s death”. Hum. Pathol., 2003, 34, 1072.

[9] Pai C.Y., Nieh S., Lee J.C., Lo C.P., Lee H.S.: “Aggressive angiomyxoma of supraclavicular fossa: a case report”. Head Neck, 2008, 30, 821.

[10] Sylvester D.C., Kortequee S., Moor J.W., Woodhead C.J., Maclennan K.A.: “Aggressive angiomyxoma of larynx: case report and literature review”. J. Laryngol. Otol., 2010, 124, 793.

[11] Skálová A., Zámecˇník M., Michal M., Opatrný V.: “Aggressive angiomyxoma presenting as polyp of uterine cavity”. Pathol. Res. Pract., 2000, 196, 719.

[12] Choi Y.D., Kim J.H., Nam J.H., Choi C., Na K.J., Song S.Y.: “Aggressive angiomyxoma of the lung”. J. Clin. Pathol., 2008, 61, 962.

[13] McCluggage W.G.: “Recent developments in vulvovaginal pathology”. Histopathology, 2009, 54, 156.

[14] Chan I.M., Hon E., Nqai S.W., Nq T.Y., Wong L.C.: “Aggressive angiomyxoma in females: is radical resection the only option?”. Acta Obstet. Gynecol. Scand., 2000, 79, 216.

[15] Han-Geurts I.J., van Geel A.N., van Doorn L., den Bakker M., Eggermont A.M., Verhoef C.: “Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery”. Eur. J. Surg. Oncol., 2006, 32, 1217.

[16] Flores E.L.N., Blanco M.A.A., Vadillo J.F., Ortiz H.C.: “Angiomixoma agresivo de la vulva. Informe de un caso y revisión de la bibliografía”. Ginecol. Obstet. Mex., 2009, 77, 487.

[17] McCluggage W.G., Jamieson T., Dobbs S.P., Grey A.: “Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropinreleasing hormone agonist therapy”. Gynecol. Oncol., 2006, 100, 623.

[18] Fine B.A., Munoz A.K., Litz C.E., Gershenson D.M.: “Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist”. Gynecol. Oncol., 2001, 81, 120.

[19] Ding D.C., Hsu S., Hsu Y.S., Chen H.T.: “Aggressive angiomyxoma of the vulva in a young female: a brief case report”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2008, 140, 128.