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Use of the ultrasound surgical aspirator in ovarian cancer: a case-control study
1Central Hospital in Rcwaland, Gyne. Dept., Stavanger, Norway
2Sinai Hospital, Division of Gyne-Oncolofy, Baltimore, Maryland, USA
3Division of Gyne-Oncology, Dartmouth Medical School & Dartmouth-Hitchcock Medical Ctr., Lebanon, NH, USA
4Department ri Biostatistics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
5Department of Obstetrics and Gynecology, Mercy Medical Institutions, Baltimore, Mw-yland, USA
*Corresponding Author(s): M. B. Sert E-mail:
Background: This study was undertaken to evaluate the use of the ultrasound surgical aspirator in ovarian cancer and to determine if cytoreduction was improved with its use.
Methods: The study is a retrospective case control trial. Twenty-six consecutive ovarian cancer patients who had the ultrasound surgical aspirator used during their surgery were retrospectively compared to 25 consecutive ovarian cancer patients who did not have the ultrasound surgical aspirator used during their surgeries. The latter group had their surgeries immediately before the ultrasound surgical aspirator was introduced into the hospital. Both groups were similar in age, stage, histology type, grade, and median number of chemotherapy cycles.
Results: Patients that had the ultrasound surgical aspirator used had a 69% optimal cytoreduction rate compared to 16% in the control group (p = .001). This was statistically significant (p = 0.001). Survival time was equal in both groups.
Conclusions: Results of the study showed that use of the ultrasound surgical aspirator may permit more patients to be optimally cytoreduced.
Ultrasound surgical aspirator; Cytoreduction
M. B. Sert,F. M. Abbas,J. L. Currie,M. L. Zahyrak,N. B. Rosenshein. Use of the ultrasound surgical aspirator in ovarian cancer: a case-control study. European Journal of Gynaecological Oncology. 2000. 21(1);24-27.
[1] Vanderburg E., Nahhas W. A.: "Debridement of vaginal radiation ulcers using the ultrasound surgical aspirator". Gynecol. Oneal., 1990, 39, 103.
[2] Rader J., Leake J., Rosenshien N.: "Use of the ultrasound aspirator in the treatment of vulvar intraepithelial neoplasia". Obstet. Gyn., 1991, 77, 151.
[3] Patsner B., Roise P.: "CUSA splenorrhaphy for ovarian cytoreduction surgery". Gynecol. Oneal., 1991, 41, 28.
[4] Adelson M. D., Haggish M. S., Seifer D. B., Cassel S. L., Thompson M. A.: "Cytoreduction of ovarian cancer with the Cavitron Ultrasound Surgical Aspirator". Obstet. Gynecol., 1988, 72, 140.
[5] Griffiths C. T., Parker L. M., Fuller A. P.: "Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma". Natl. Cancer Inst. Monog.,1975, 42, 101.
[6] Wharton J. T., Herson J.: "Surgery for common epithelial tumors of the ovary". Cancer, 1981, 48, 582.
[7] Hacker N. F., Berek J. S., Lagasse L. D. et al.: "Primary cytoreductive surgery for epithelial ovarian cancer". Obstet. Gynecol., 1983, 61, 413.
[8] Kaplan E. L., Meier P.: "Nonparametric estimation from incomplete observations". J. Am. Stat. Assoc., 1958, 53, 457.
[9] Mantel N., Haenszel W.: "Statistical aspects of the analysis of data from retrospective studies of disease". J. Natl. Cancer Inst., 1959, 22, 719.
[10] Cox D. R.: "Regression models and life tables (with discussion)". J. of the Royal Stat. Soc. B., 1972, 34, 187.
[11] National Cancer Institute: "Division of Cancer Prevention and Control". Annual Cancer Statistics Review, Bethesda, NIH Publication, 1986, 87, 2789.
[12] Goldie J. H., Coldman A. J.: "A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate". Cancer Treat. Rep., 1979, 63, 1727.
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