Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Cauda equina compression in breast cancer -incidence and treatment outcome
1Departments of Radiology, Louisiana State University Health Sciences Center Shreveport, Louisiana, USA
2Departments of Medicine, Louisiana State University Health Sciences Center Shreveport, Louisiana, USA
3Departments of Neurosurger, Louisiana State University Health Sciences Center Shreveport, Louisiana, USA
*Corresponding Author(s): F. L. Ampil E-mail:
Purpose: To determine the incidence and treatment outcome of compression of the cauda equina by metastatic disease in patients with breast cancer.
Methods: A retrospective study of individuals diagnosed with breast cancer at a single institution during a 16-year period was undertaken.
Results: Of the 1,283 patients studied, 15 (1.2%) developed cauda equina syndrome from metastatic disease. The median survival was eight months; ten (67%) survived for at least six months. Among the evaluable patients, pain was completely relieved in eight of ten women; complete resolution of neurologic deficits was observed in five of nine patients.
Conclusion: Metastatic breast cancer compression of the cauda equina and long-term survival of patients are infrequent occurrences. Beneficial responses can be mediated by radiotherapy.
Cauda Equina Compression; Breast Cancer; Radiotherapy
F. L. Ampil,G. V. Burton,G. M. Mills,A. Jawahar,R. Pelser,A. Nanda. Cauda equina compression in breast cancer -incidence and treatment outcome. European Journal of Gynaecological Oncology. 2001. 22(4);257-259.
[1] Boogerd W., Vos V.W., Hart A.A.M., Baris G.: "Brain metastases in breast cancer: Natural history, prognostic factors and outcome". J. Neuro-Oncol., 1993, 15, 165.
[2] Boogerd W., Hart A.A.M., Yan der Sande J.J., Engelsman E: "Meningeal carcinomatosis in breast cancer: Prognostic factors and influence of treatment". Cancer, 1991, 67, 1685.
[3] DiStefano A., Yap H.Y.. Hortobagyi G.N.. Blumenschein G.R: "The natural history of breast cancer patients with brain metastases". Cancer, 1979, 44. 1913.
[4] Harrison K.M.. Muss H.B., Ball M.R., McWhorter M., Case D.: "Spinal cord compression in breast cancer". Cancer, 1985, 55, 2839.
[5] Schabet M., Kloeter I., Adam T., Heidemann E., Wietholter H.: "Diagnosis and treatment of meningeal carcinomatosis in ten patients with breast cancer". Eur. Neural., 1986, 25, 403.
[6] Sorensen S.C., Eagan R.T., Scott M.: "Meningeal carcinomatosis in patients with primary breast or lung cancer". Mayo Clinic Proc., 1984, 59, 91.
[7] Yap H.Y., Yap B.S., Rasmussen S., Levens M.E., Hortobagyi G.N.. Blumenschein G.R.:'Treatment for meningeal carcinomatosis in breast cancer". Cancer, 1982, 49, 219.
[8] Hill M.E., Richards M.A., Gregory W.M., Smith P., Rubens R.D.: "Spinal cord compression in breast cancer: a review of 70 cases" Br. J. Cancer, 1973, 68, 969.
[9] Tatsui H., Onomura T., Morishita S., Oketa M., Inoue T.: "Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation". Spine, 1996, 21, 2143.
[10] Patanaphan V., Salazar O.M.. Risco R.: "Breast cancer: metastatic patterns and their prognosis". South. Med. J., 1988, 81, 1109.
[11] Boogerd W., Van der Sande J.J., Kroger R.:''Early diagnosis and treatment of spinal epidural metastasis in breast cancer: a prospective study". J. Neural. Neurosurg. Psychiatry, 1992, 95, 1188.
[12] Gilbert R.W., Kim J.H., Posner J.B.: "Epidural spinal cord compression from metastatic tumor: diagnosis and treatment". Ann Neural., 1978, 3, 40.
[13] Sorensen P.S., Borgesen S.E., Rohde K., Rasmusson B., Bach F., Boge-Rasmussen T., Stjernholm P. et al.: "Metastatic epidural spinal cord compression, results of treatment and survival" Cancer, 1990, 65, 1502.
Top