The significance of local cellular immune response of women 50 years of age and younger with endometrial carcinoma

Objective: Local cellular immune response and traditional histopathologic parameters in endometrial carcinoma patients 50 years old and younger were compared with those of patients older than 50 years of age.

Materials and methods: We retrospectively compared the clinicopathologic factors and outcomes of 24 younger and 82 older women who were operated on for endometrioid type endometrial carcinoma at our institution.

Results: No significant difference was determined in survival with respect to age and menopausal status in patients with endometrial carcinoma. Younger and older age groups had a similar distribution of most pathologic features including myometrial invasion, cervical involvement, lymph node metastasis, vascular invasion, perivascular lymphocytic infiltrates and tumor infiltrating lymphocytes. While older women had higher-grade tumors, younger women had more frequent ovarian metastasis. Tumor infilrating lymphocytes were seen more frequently in the postmenopausal group than those of the premenopausal group.

Conclusion: The distribution of local cellular immune response, most histopathologic parameters and survival were the same for younger and older women.

Endometrial carcinoma; Age; Menopausal status; Local cellular immune response; Traditional histopathologic parameters

[1] Lurain J. R.: "Uterine cancer". In: Berek J. S. (ed): Novak'.,· Gynecology. 12',, ed., Baltimore, Wiiliams and Wilkins, 1996. 1061.

[2] Aziz H.. Hussain F., Edelman S., Cirrone J., Aral I., Fruchter R.. et al.: "Age and race as prognostic factors in endometrial carcinoma". Am. J. Clin. Oneal., 1996, 19, 595.

[3] Kaku T., Matsumara M., Sakai K.. Tsuruchi N., Kamura T., Tsukamoto N. et ul.: "Endometrial carcinoma in women 65 years of age or older: a clinicopathologic study". Eur. J. Gynecol. Oneal., 1996, 17, 357.

[4] Yamazawa K., Seki K., Matsui H.. Kihora M., Sekiya S.: "Prognostic factors in young women with endometrial carcinoma: a report of 20 cases and review of the literature". Int. J. Gynecol Cancer, 2000, 10, 212.

[5] Evans-Metcalf E. R.. Brooks S. E.. Reale F. R.. Baker S. P.: "Profile of women 45 years of age and younger with endometrial cancer". Obstet. Gynecol., 1998, 91, 349.

[6] Tran B. N., Connell P. P.. Waggoner S., Rotmensch J., Mundt A J.: "Characteristics and outcome of endometrial carcinoma patients age 45 years and younger". Am. J. Clin. Oncol., 2000, 23, 476.

[7] Mundt A. J.. Waggoner S., Yamda D., Rotmensch J., Connell P. P.: "Age as a prognostic factor for recurrence in patients with endometrial carcinoma". Gynecol. Oneal., 2000, 79, 79.

[8] Lang J. R., Davidorf F. H.. Baba N.: "The prognostic significance of lymphocytic infiltration in malignant melanoma of the choroid". Cancer, 1977, 40, 2388.

[9] Di Giorgio A., Botti C., Tocchi A., Mingaaini P., Flammia M: 'The influence of tumor lymphocytic infiltration on long term survival of surgically treated colorectal cancer patients". Int. Surg., 1992, 77, 256.

[10] Wolf G. T., Hudson J. L., Peterson K. A., Miller H. L., McClatchey K. D.: "Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: correlations with extent of tumor and prognoslS“ Otolar}ngol Head Neck Surg, 1986, 95, 142.

[11] Das S. N., Khanna N. N.. Khanna S.: "In vivo and in vitro observation of cellular immune parameters in 、quamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis" Cancer Invest., 1986, 4, 207.

[12] Braghieri G., Gabrielli M., Bobbio P.: "Local cellular immune response in bronchopulmonary carcinoma atier surgery in relation to long-term prognosis". Actu Biomed Ateneo Purmanse, 1982, 53, 289.

[13] Ambros R. A., Kurman R. J.: "Combined assessment of vascular and myometrial inv小ion as a model to predict prognosis in stage I endometrioid adenocarcinoma of the uterine corpus". Cancer, 1992, 69, 1424.

[14] Lee K. R., Vacek P. M., Belinson J. L.:'Traditional and nontradional histopathologic predictors of recurrence in uterine endometrioid adenocarcinoma". Gynecol. Oncol., 1994, 54, 10.

[15] Yamazawa K, Seki K, Matsui H, Seki ya S: "Significance of penvascular lymphocytic infiltrates in endometrial carcinoma" Cancer., 2001, 91, 1777.

[16] Abeler V. M., Kjorstad K. E.: "Endometrial carcinoma in Norway. A study of total population". Cancer, 1991, 67, 3093.

[17] Deligdisch L. "Morphological corralates of host response in endometrial carcinoma". Am. J. Reprod. lmmunol., 1982, 2, 54

[18] Silverberg S. G., Sasano N, Yajima A: "Endornetrial carcinoma in Miyagi Prefecture, Japan: histopathologic analysis of a cancer registry-based series and comparison with cases in American women". Cancer, 1982, 49, 1504.